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Four evolutionary strata on the human X chromosome.
Human sex chromosomes evolved from autosomes. Nineteen ancestral autosomal genes persist as differentiated homologs on the X and Y chromosomes. The ages of individual X-Y gene pairs (measured byExpand
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Geometric cues for directing the differentiation of mesenchymal stem cells
Significant efforts have been directed to understanding the factors that influence the lineage commitment of stem cells. This paper demonstrates that cell shape, independent of soluble factors, has aExpand
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Functional coherence of the human Y chromosome.
A systematic search of the nonrecombining region of the human Y chromosome (NRY) identified 12 novel genes or families, 10 with full-length complementary DNA sequences. All 12 genes, and six of eightExpand
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Evolutionary and Biomedical Insights from the Rhesus Macaque Genome
The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologicallyExpand
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Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine
In contrast to 5-methylcytosine (5-mC), which has been studied extensively, little is known about 5-hydroxymethylcytosine (5-hmC), a recently identified epigenetic modification present in substantialExpand
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Accelerated Evolution of Nervous System Genes in the Origin of Homo sapiens
Human evolution is characterized by a dramatic increase in brain size and complexity. To probe its genetic basis, we examined the evolution of genes involved in diverse aspects of nervous systemExpand
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Systematic Comparison of Constitutive Promoters and the Doxycycline-Inducible Promoter
Constitutive promoters are used routinely to drive ectopic gene expression. Here, we carried out a systematic comparison of eight commonly used constitutive promoters (SV40, CMV, UBC, EF1A, PGK andExpand
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Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity
Postcopulatory sperm competition is a key aspect of sexual selection and is believed to drive the rapid evolution of both reproductive physiology and reproduction-related genes. It isExpand
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Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis
  • B. Lahn, Z. Tang, +4 authors D. Page
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 18 June 2002
During spermiogenesis (the maturation of spermatids into spermatozoa) in many vertebrate species, protamines replace histones to become the primary DNA-packaging protein.It has long been thought thatExpand
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Nestin Is Required for the Proper Self‐Renewal of Neural Stem Cells
The intermediate filament protein, nestin, is a widely employed marker of multipotent neural stem cells (NSCs). Recent in vitro studies have implicated nestin in a number of cellular processes, butExpand
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