• Publications
  • Influence
Different modulation by histamine of IL‐4 and interferon‐gamma (IFN‐γ) release according to the phenotype of human Th0, Th1 and Th2 clones
Histamine, an important inflammatory mediator in allergic diseases and asthma, has been reported to have modulator effects on T cells, suggesting that the bronchial microenvironment may regulate theExpand
  • 83
Effect of stimulation of human macrophages on intracellular survival of Mycobacterium bovis Bacillus Calmette-Guerin. Evaluation with a mycobacterial reporter strain.
The mechanisms through which immune and inflammatory responses stimulate the expression of antimycobacterial activity by human macrophages remain poorly defined. To study this question, we developedExpand
  • 24
Phenotype of T cell clones obtained from bronchial biopsies and peripheral blood from three asthmatics.
Establishment of T cell clones derived from bronchial biopsies and peripheral blood from allergic asthmatics has shown that they secret a different IL‐4 and IFN‐γ pattern of cytokines, suggestingExpand
  • 15
Differences in IL-4 release by PBMC are related with heterogeneity of atopy.
Atopy is heterogeneous and the IgE immune response of patients allergic to a single allergen (monosensitized) differs from that of those allergic to multiple allergens (polysensitized). SinceExpand
  • 72
Seasonal variations of interleukin-4 and interferon-γ release by peripheral blood mononuclear cells from atopic subjects stimulated by polyclonal activators
Abstract IgE synthesis is controlled by interleukin (IL)-4 and interferon (IFN)-γ, but there is heterogeneity in the IL-4 response depending on the sensitization of patients and natural allergenExpand
  • 40
  • PDF
Seasonal variations of interleukin-4 and interferon-gamma release by peripheral blood mononuclear cells from atopic subjects stimulated by polyclonal activators.
IgE synthesis is controlled by interleukin (IL)-4 and interferon (IFN)-gamma, but there is heterogeneity in the IL-4 response depending on the sensitization of patients and natural allergen exposure.Expand
  • 23
Nicotine does not modulate IL-4 and interferon-gamma release from peripheral blood mononuclear cells and T cell clones activated by phorbol myristate acetate and calcium ionophore.
Tobacco smoking induces an increased nonspecific IgE response. IgE synthesis is controlled by IL-4 and IFN-gamma. The effect of nicotine (10(-10) to 10(-5) M), one of the major components of tobaccoExpand
  • 12
Subject Index, Vol. 111 1996
Contents, Vol. Ill, 1996