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- Publications
- Influence
Different modulation by histamine of IL‐4 and interferon‐gamma (IFN‐γ) release according to the phenotype of human Th0, Th1 and Th2 clones
- B. Lagier, B. Lebel, J. Bousquet, J. Pène
- Biology, Medicine
- Clinical and experimental immunology
- 1 June 1997
Histamine, an important inflammatory mediator in allergic diseases and asthma, has been reported to have modulator effects on T cells, suggesting that the bronchial microenvironment may regulate the… Expand
Effect of stimulation of human macrophages on intracellular survival of Mycobacterium bovis Bacillus Calmette-Guerin. Evaluation with a mycobacterial reporter strain.
- M. Bonay, F. Bouchonnet, +7 authors A. Hance
- Biology, Medicine
- American journal of respiratory and critical care…
- 1 May 1999
The mechanisms through which immune and inflammatory responses stimulate the expression of antimycobacterial activity by human macrophages remain poorly defined. To study this question, we developed… Expand
Phenotype of T cell clones obtained from bronchial biopsies and peripheral blood from three asthmatics.
- J. Pène, B. Lagier, A. Rivier, P. Chanez, J. Vendrell, J. Bousquet
- Biology, Medicine
- Cell biology international
- 1 March 1993
Establishment of T cell clones derived from bronchial biopsies and peripheral blood from allergic asthmatics has shown that they secret a different IL‐4 and IFN‐γ pattern of cytokines, suggesting… Expand
Differences in IL-4 release by PBMC are related with heterogeneity of atopy.
Atopy is heterogeneous and the IgE immune response of patients allergic to a single allergen (monosensitized) differs from that of those allergic to multiple allergens (polysensitized). Since… Expand
Seasonal variations of interleukin-4 and interferon-γ release by peripheral blood mononuclear cells from atopic subjects stimulated by polyclonal activators
Abstract IgE synthesis is controlled by interleukin (IL)-4 and interferon (IFN)-γ, but there is heterogeneity in the IL-4 response depending on the sensitization of patients and natural allergen… Expand
Seasonal variations of interleukin-4 and interferon-gamma release by peripheral blood mononuclear cells from atopic subjects stimulated by polyclonal activators.
- B. Lagier, N. Pons, +4 authors J. Pène
- Biology, Medicine
- The Journal of allergy and clinical immunology
- 1 June 1996
IgE synthesis is controlled by interleukin (IL)-4 and interferon (IFN)-gamma, but there is heterogeneity in the IL-4 response depending on the sensitization of patients and natural allergen exposure.… Expand
Nicotine does not modulate IL-4 and interferon-gamma release from peripheral blood mononuclear cells and T cell clones activated by phorbol myristate acetate and calcium ionophore.
- L. Le Cam, B. Lagier, J. Bousquet, J. Pène
- Medicine
- International archives of allergy and immunology
- 1 December 1996
Tobacco smoking induces an increased nonspecific IgE response. IgE synthesis is controlled by IL-4 and IFN-gamma. The effect of nicotine (10(-10) to 10(-5) M), one of the major components of tobacco… Expand