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Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrin.
TLDR
The gamma 2 subunit and gephyrin are interdependent components of the same synaptic complex that is critical for postsynaptic clustering of abundant subtypes of GABAA receptors in vivo.
Postsynaptic clustering of major GABAA receptor subtypes requires the γ2 subunit and gephyrin
TLDR
The γ2 subunit and gephyrin are interdependent components of the same synaptic complex that is critical for postsynaptic clustering of abundant subtypes of GABAA receptors in vivo.
Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive
TLDR
It is shown that the arginine methyltransferase PRMT6 catalyses H3R2 di-methylation in vitro and controls global levels of H 3R2me2a in vivo, and that the mutual antagonism between H2R2 and H3K4 methylation, together with the association of MLL-family complexes with the basal transcription machinery, may contribute to the localized patterns of H3k4 tri-methylated promoters in mammalian genomes.
Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter.
TLDR
It is shown that Myc is bound to the cyclin D2 promoter in vivo, and recruitment of TRRAP and regulation of histone acetylation are critical for transcriptional activation by Myc.
Myc and Max associate in vivo.
TLDR
It is shown here, by means of a coimmunoprecipitation assay with anti-Myc and anti-Max antibodies, that Myc and Max are associated in vivo and essentially all of the newly synthesized Myc can be detected in a complex with Max.
Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity.
TLDR
The findings strongly suggest that AP-4 contains multiple protein-protein interfaces that function to promote homodimer formation and restrict heterocomplexes, and provide a mechanism by which different members of the helix-loop-helix family of transcription factors can form functional dimers in a specific fashion with their appropriate partners to control transcriptional networks during cellular differentiation.
The GDP-GTP Exchange Factor Collybistin: An Essential Determinant of Neuronal Gephyrin Clustering
TLDR
The characterization of several new variants of collybistin are reported, which are created by alternative splicing of exons encoding an N-terminal src homology 3 (SH3) domain and three alternate C termini (CB1, CB2, and CB3).
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