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Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells.
It is the first report that cryptotanshinone has antitumor activity through the inhibition of STAT3, a potent anticancer agent targeting the activation STAT3 protein.
KRIBB11 Inhibits HSP70 Synthesis through Inhibition of Heat Shock Factor 1 Function by Impairing the Recruitment of Positive Transcription Elongation Factor b to the hsp70 Promoter*
Chromatin immunoprecipitation analysis showed that KRIBB11 inhibited HSF1-dependent recruitment of p-TEFb (positive transcription elongation factor b) to the hsp70 promoter, which strengthens the rationale for targeting HSF 1 in cancer therapy.
Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation.
Blocking Tumor Cell Migration and Invasion with Biphenyl Isoxazole Derivative KRIBB3, a Synthetic Molecule That Inhibits Hsp27 Phosphorylation*
Overall, the results demonstrate that KRIBB3 inhibits tumor cell migration and invasion by blocking protein kinase C-dependent phosphorylation of Hsp27 through its direct binding to HSP27.
Cytotoxic components from the dried rhizomes of Zingiber officinaleRoscoe
Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography and 6-shogaol exhibited the most potent cytotoxicity against human A549,SK-OV-3, SK-MEL-2, and HCT15 tumor cells.
Ginkgetin inhibits the growth of DU−145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity
This is the first report that ginkgetin exerts antitumor activity by inhibiting STAT3, and may be a useful lead molecule for development of a therapeutic STAT3 inhibitor.
Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells.