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New Lessons for Combinatorial Biosynthesis from Myxobacteria
TLDR
The biosynthetic mta gene cluster responsible for myxothiazol formation from the fruiting body forming myxobacterium Stigmatella aurantiaca DW4/3-1 was sequenced and analyzed and provided insight into the mechanism of the formation of the terminal amide of myxOTHiazol.
Apicularens A and B, new cytostatic macrolides from Chondromyces species (myxobacteria): production, physico-chemical and biological properties.
TLDR
A novel macrolide, apicularen A, was produced by several species of the genus Chondromyces, and is chemically closely related to the salicylihalamides A and B from the marine sponge Haliclona sp.
Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase
TLDR
Alkalizing reagents, specifically those already used in humans for other applications, and vacuolar ATPase inhibitors may be therapeutically used to prevent GRN-dependent neurodegeneration.
Archazolid and apicularen: Novel specific V-ATPase inhibitors
TLDR
The myxobacterial antibiotics archazolid and apicularen are highly efficient and specific novel inhibitors of V-ATPases.
Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase.
TLDR
The effect of ten naturally occurring and two synthetic inhibitors of NADH:ubiquinone oxidoreductase (complex I) of bovine heart, Neurospora crassa and Escherichia coli and fructose dehydrogenase of Gluconobacter oxidans was investigated.
New Structural Variants of Homoserine Lactones in Bacteria
TLDR
The results show that these compounds display varying responses to the respective sensors; this underlines the importance of determining the whole bouquet of AHLs and its function to fully understand their importance for regulatory functions in bacteria.
The Biosynthesis of the Aromatic Myxobacterial Electron Transport Inhibitor Stigmatellin Is Directed by a Novel Type of Modular Polyketide Synthase*
TLDR
Results of feeding experiments are in good agreement with the proposed biosynthetic scheme, and in contrast to all other PKS type I systems reported to date, each module of StiA–J is encoded on a separate gene.
The aurachins, new quinoline antibiotics from myxobacteria: production, physico-chemical and biological properties.
TLDR
The aurachins, new quinoline alkaloids, were extracted with acetone from the biomass of the myxobacterium, Stigmatella aurantiaca strain Sg a15 and purified by column chromatography and were inhibitory for Gram-positive bacteria and a few yeasts and molds.
Damage of Streptococcus mutans biofilms by carolacton, a secondary metabolite from the myxobacterium Sorangium cellulosum
TLDR
It is shown that carolacton, a secondary metabolite isolated from Sorangium cellulosum, has high antibacterial activity against biofilms of S. mutans and may represent a novel approach for the prevention of dental caries.
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