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Model studies for evaluating the neurobehavioral effects of complex hydrocarbon solvents III. PBPK modeling of white spirit constituents as a tool for integrating animal and human test data.
As part of a project designed to develop a framework for extrapolating acute central nervous system (CNS) effects of hydrocarbon solvents in animals to humans, experimental studies were conducted inExpand
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The IPCS Collaborative Study on Neurobehavioral Screening Methods: II. Protocol design and testing procedures.
This paper describes the development of the protocol for the International Programme on Chemical Safety (IPCS)-sponsored Collaborative Study on Neurobehavioral Screening Methods, including backgroundExpand
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The effects of 4‐aminopyridine on cognitive function in patients with multiple sclerosis
4 Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized,Expand
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Mid-frequency hearing loss and reduction of acoustic startle responding in rats following trichloroethylene exposure.
Modification of auditory evoked startle responding using prepulse inhibition was used to examine the effects of trichloroethylene (TCE) exposure on auditory thresholds. Rats were exposed byExpand
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The IPCS collaborative study on neurobehavioral screening methods.
The International Programme on Chemical Safety sponsored a collaborative study to evaluate the utility of neurobehavioral test methods for identifying neurotoxic chemicals. The protocol consisted ofExpand
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Simultaneous exposure to ethyl benzene and noise: synergistic effects on outer hair cells
The effects on hearing of simultaneous exposure to the ototoxic organic solvent ethyl benzene and broad-band noise were evaluated in rats. The effects of three ethyl benzene concentrations (0, 300 orExpand
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Differential susceptibility of rats and guinea pigs to the ototoxic effects of ethyl benzene.
The present study was designed to compare the ototoxic effects of volatile ethyl benzene in guinea pigs and rats. Rats showed deteriorated auditory thresholds in the mid-frequency range, based onExpand
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Noise-induced hearing loss in rats.
The effect of noise exposure on the auditory system is well known from animal studies. However, most of the studies concern short-term exposure conditions. The purpose of the present research was toExpand
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Effects of the PCB 3,4,5,3′,4′,5′-hexachlorobiphenyl on the reproduction capacity of Wistar rats
Abstract Groups of rats were administered different doses of the coplanar PCB 3,4,5,3′,4′,5′-hexachlorobiphenyl or vehicle on day 1 of gestation. Slight maternal toxicity was evidenced by temporarilyExpand
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Neurobehavioral Effects of Acute Exposure to Aromatic Hydrocarbons
This article reports the results of neurobehavioral tests on representative aromatic constituents, specifically C9 to C11 species. The testing evaluated effects in several domains including clinicalExpand
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