• Publications
  • Influence
Modulation of the Mesolimbic Dopamine System by Glutamate
  • B. Kretschmer
  • Chemistry, Medicine
  • Journal of neurochemistry
  • 1 August 1999
Abstract : Glutamate has been shown to modulate motor behavior, probably via N‐methyl‐d‐aspartate (NMDA) and α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptors that are involved inExpand
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Riluzole, a glutamate release inhibitor, and motor behavior
Riluzole (2-amino-6-trigluoromethoxy benzothiazole) has neuroprotective, anticonvulsant, anxiolytic and anesthetic qualities. These effects are mediated by blockade of glutamate transmission,Expand
  • 73
  • 5
The ventral pallidum mediates disruption of prepulse inhibition of the acoustic startle response induced by dopamine agonists, but not by NMDA antagonists
Prepulse inhibition (PPI) of the acoustic startle response is observed when the startling noise pulse is preceded by a weak, non-startling stimulus. PPI has been considered as a measure forExpand
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Role of the strychnine-insensitive glycine binding site in the nucleus accumbens and anterodorsal striatum in sensorimotor gating: a behavioral and microdialysis study
Abstract This study examined the role of the strychnine-insensitive glycine binding site of the NMDA receptor in prepulse inhibition (PPI) of the acoustic startle response (ASR) in rats. PPI is anExpand
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State‐dependent blockade of haloperidol‐induced sensitization of catalepsy by MK‐801
NMDA receptor antagonists have been shown to block several forms of neural and behavioural plasticity. The prototypical and most widely‐used noncompetitive NMDA receptor antagonist is dizocilpineExpand
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Role of the substantia nigra pars reticulata in sensorimotor gating, measured by prepulse inhibition of startle in rats
The substantia nigra pars reticulata (SNR) is one of the major output nuclei of the basal ganglia. It connects the dorsal and ventral striatum with the thalamus, superior colliculus andExpand
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Glutamate and GABA modulate dopamine in the pedunculopontine tegmental nucleus
The pedunculopontine tegmental nucleus (PPTg) has an important anatomical position connecting basal ganglia and limbic systems with motor execution structures in the pons and spinal cord. It receivesExpand
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Behavioural pharmacology of glutamate receptors in the basal ganglia
Glutamate receptors play a major role in the transmitter balance within the basal ganglia (BG). N-methyl-D-aspartate (NMDA) receptor stimulation within the striatum acts behaviourally depressantExpand
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ACEA 1021, a glycine site antagonist with minor psychotomimetic and amnestic effects in rats.
Antagonists of the allosteric glycine site of the NMDA receptor complex have been suggested to be beneficial in the treatment of neurodegenerative disorders. However, unwanted side effects likeExpand
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Modulatory role of food, feeding regime and physical exercise on body weight and insulin resistance.
Energy intake and expenditure is a highly conserved and well-controlled system with a bias toward energy intake. In times of abundant food supply, individuals tend to overeat and in consequence toExpand
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