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Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates.
Five tacrine-ferulic acid hybrids (6a-e) were designed and synthesized as multi-potent anti-Alzheimer drug candidates. All target compounds have better acetylcholinesterase inhibitory activity andExpand
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Hyperforin is a modulator of inducible nitric oxide synthase and phagocytosis in microglia and macrophages
Upon activation, microglia, the immunocompetent cells in the brain, get highly phagocytic and release pro-inflammatory mediators like nitric oxide (NO). Excessive NO production is pivotal inExpand
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Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis.
Xanthohumol (XN) is a major prenylated chalcone found in hops, which is used to add bitterness and flavor to beer. In this study, we first investigated the effects of XN on hepatocytes and hepaticExpand
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Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo.
A codrug of the anti-Alzheimer drug tacrine and the natural product silibinin was synthesized. The codrug's biological and pharmacological properties were compared to an equimolar mixture of theExpand
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Effect of choline carboxylate ionic liquids on biological membranes.
Choline carboxylates, ChCm, with m=2-10 and choline oleate are known as biocompatible substances, yet their influence on biological membranes is not well-known, and the effect on human skin has notExpand
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Linear fluorescence unmixing in cell biological research
One of the most important issues in biomedical research microscopy is the analysis of the spatial localization of fluorescently labelled structures. Today, a wide range of available dyes, fluorescentExpand
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In vitro structure-toxicity relationship of chalcones in human hepatic stellate cells.
Xanthohumol (XN), the major prenylated chalcone from hops (Humulus lupulus L.), has received much attention within the last years, due to its multiple pharmacological activities includingExpand
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Diarylheptanoid Glycosides of Morella salicifolia Bark
A methanolic extract of Morella salicifolia bark was fractionated by various chromatographic techniques yielding six previously unknown cyclic diarylheptanoids, namely, 7-hydroxymyricanolExpand
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Biodegradability and cytotoxicity on human cell lines of choline soaps: effects of chain length and cation
Using choline as a counterion in fatty acid surfactants substantially increases their H2O soly. as compared to classical Na and K soaps, and thereby enables the application of desirable longer-chainExpand
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Acyloxybutadiene iron tricarbonyl complexes as enzyme-triggered CO-releasing molecules (ET-CORMs).
Molecular hazardous materials transport: Enzyme-triggered CO-releasing molecules (ET-CORMs) offer new options for the delivery of CO. The cleavage of dienylester iron tricarbonyl complexes by anExpand
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