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The Use of TDM Data to Assess the Validity of Defined Daily Doses of Antiepileptics: A Comparison Between a Czech and Swedish University Hospital
TLDR
The data suggest that the DDDs of AEDs should be reconsidered as, in the majority of cases, they appear to be too high. Expand
Cyclosporine A area-under-time-concentration-curve in rheumatologic patients after the first dose. Which of the sparse sampling strategies will predict the best?
TLDR
Equations validated for prediction of AUC of cyclosporine A after the first dose in rheumatologic patients might be used for LSS:s of CsA independently of the length of treatment, indication, dosage or galenic formulation. Expand
[Comparison of the consumption of antiepileptic drugs in the Czech Republic, Scandinavia, and Australia].
TLDR
Long-term trends in utilization of antiepileptic drugs expressed in DDD/TID according to the 4th ATC level were studied and Benzodiazepins were the most widely utilized group in Finland, until 1995 also in Australia, from 1996 in Norway. Expand
Differences between prescribed daily doses and defined daily doses of antiepileptics--therapeutic drug monitoring as a marker of the quality of the treatment.
TLDR
PDDs in monotherapy were similar or slightly lower than in combination therapy with an exception for lamotrigine, NS and plasma levels tended to be below the therapeutic range. Expand
Lamotrigine drug interactions in combination therapy and the influence of therapeutic drug monitoring on clinical outcomes in paediatric patients
TLDR
Despite poor correlation with TR, both seizure frequency and ADRs declined after the implementation of TDM, and a significantly higher number of supratherapeutic lamotrigine levels were found in combinations with valproate. Expand
Lamotrigine Drug Interactions in Combination Therapy and the Influence of Therapeutic Drug Monitoring on Clinical Outcomes of Adult Patients
Background: The aim was to study the impact of therapeutic drug monitoring (TDM) on patients on lamotrigine (LTG) therapy and the evaluation of possible drug interactions, especially in tripleExpand
Therapeutic Monitoring of Antiepileptic Drugs: A Comparison Between a Czech and a Swedish University Hospital
TLDR
Drug treatment of epilepsy in two hospitals is surprisingly similar in terms of achieved plasma concentrations, in spite of socioeconomic and cultural differences between the authors' two countries. Expand
Significant discrepancy in cyclosporin A post-dose concentrations when analyzed with specific RIA and HPLC method.
TLDR
The ratio of metabolites/parent drug after CsA intake is decreasing but their absolute concentrations are significantly increasing, and TDM using C(2) and AUC sparse sampling may cause misleading interpretation using both methods alternately for the same patient. Expand
Validation of Sparse Sampling Strategies to Estimate Cyclosporine A Area Under the Concentration-Time Curve Using Either a Specific Radioimmunoassay or High-Performance Liquid Chromography Method
TLDR
The validation of equations is of major importance for prediction precision, whereas the analytical method for limited sampling strategy proposals had no influence in the results. Expand
The possibility of using the specific RIA method for the area-under-time-concentration curve sparse sampling calculation of cyclosporin A despite a large post-dose overestimation.
TLDR
LSS:s can moderate the interassay %PE in AUC of CsA, and repeated analysis with HPLC is suggested in cases with AUC:s results close to the lower or upper margin of the therapeutic window. Expand
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