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Antiviral l-Nucleosides Specific for Hepatitis B Virus Infection
TLDR
A unique series of simple “unnatural” nucleosides has been discovered to inhibit hepatitis B virus (HBV) replication and are expected to offer new therapeutic options for patients with chronic HBV infection. Expand
Small-Molecule Effectors of Hepatitis B Virus Capsid Assembly Give Insight into Virus Life Cycle
TLDR
This work takes advantage of heteroaryldihydropyrimidines, which affect hepatitis B virus assembly, to gain insight and correlate in vitro assembly with HBV replication in culture, and develops a predictive and testable model for the mechanism of action of assembly effectors. Expand
Hepatitis B virus cell culture assays for antiviral activity.
TLDR
This assay system, described here, is currently that used by the National Institutes of Health-National Institute of Allergy and Infectious Diseases (NIH-NIAID) as an in vitro screen for antiviral agents against HBV replication. Expand
Enhanced oral absorption and antiviral activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and related compounds in hepatitis B virus infection, in vitro.
TLDR
Lipid prodrugs of this type may be useful orally in treating viral diseases and urinary recovery of tritium after oral or parenteral administration of the radiolabeled compounds, oral absorption of ODG-P-ACV in mice was 100% versus 37% for ACV. Expand
Phosphatidyl-2',3'-dideoxy-3'-thiacytidine: synthesis and antiviral activity in hepatitis B-and HIV-1-infected cells.
TLDR
In HIV-1-infected human peripheral blood mononuclear cells and HT4-6C cells, phosphatidyl-3TC and phosph atidyl-(+/-)-BCH-189 exhibited significantly lower activity than the corresponding free nucleosides. Expand
Liver‐targeted antiviral nucleosides: Enhanced antiviral activity of phosphatidyl‐dideoxyguanosine versus dideoxyguanosine in woodchuck hepatitis virus infection in vivo
TLDR
The data suggest that the use of lipid prodrugs to target the liver may be useful in enhancing antiviral therapy of hepatitis. Expand
Animal Models for HBV Infections — Transgenic Mice
TLDR
This chapter describes the features of the HBV-transgenic mice that produce appreciable levels of serum hepatitis B virions, as determined by the presence of HBV DNA and electron microscopy. Expand
Running title : Targeting virus assembly Small-Molecule Effectors of Hepatitis B Virus Capsid Assembly Give Insight Into Virus Lifecycle
word count: 203 d – current address 250 McElroy Hall Department of Veterinary Pathobiology Oklahoma State University Stillwater, Oklahoma 74078-2007 e* current address, corresponding author AdamExpand