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The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease.
The galanin peptide family consists of the "parental" galanin, galanin-message-associated peptide (GMAP) which derives from the same peptide precursor gene product as galanin, galanin-like peptideExpand
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Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity
Galanin was first identified 30 years ago as a "classic neuropeptide," with actions primarily as a modulator of neurotransmission in the brain and peripheral nervous system. OtherExpand
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No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis
The Warburg effect describes the circumstance that tumor cells preferentially use glycolysis rather than oxidative phosphorylation for energy production. It has been reported that this metabolicExpand
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Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinoma.
To elucidate the relationship between tumor genesis and the mitochondrial energy metabolism in renal neoplasms, we studied three individual enzyme activities of the oxidative phosphorylation, twoExpand
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Loss of Complex I due to Mitochondrial DNA Mutations in Renal Oncocytoma
Purpose: Many solid tumors exhibit abnormal aerobic metabolism characterized by increased glycolytic capacity and decreased cellular respiration. Recently, mutations in the nuclear encodedExpand
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Galanin receptor subtype GalR2 mediates apoptosis in SH-SY5Y neuroblastoma cells.
Recently we have shown that galanin binding significantly correlates with survival in neuroblastoma patients, indicating a possible modulatory role of galanin receptors in neuroblastic tumor biology.Expand
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The Mitochondrial T16189C Polymorphism Is Associated with Coronary Artery Disease in Middle European Populations
Background The pivotal role of mitochondria in energy production and free radical generation suggests that the mitochondrial genome could have an important influence on the expression ofExpand
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Pharmacological and functional characterization of galanin-like peptide fragments as potent galanin receptor agonists
The hypothalamic galanin-like peptide (GALP) was isolated by its ability to activate galanin receptors. The mature porcine GALP is a 60-amino acid neuropeptide proteolytically processed from aExpand
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Gangliocytes in neuroblastic tumors express alarin, a novel peptide derived by differential splicing of the galanin-like peptide gene
In neuroblastic tumors a relationship of differentiation of the tumor to galanin receptor expression and antip roliferative and apoptotic effects upon activation of galanin receptors in neuroblastomaExpand
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Alarin is a vasoactive peptide
Galanin-like peptide (GALP) is a hypothalamic neuropeptide belonging to the galanin family of peptides. The GALP gene is characterized by extensive differential splicing in a variety of murineExpand
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