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The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease.
The wide range of functions of the galanin peptide family indicates an essential role for Galanin signaling in "mind and body homeostasis" and a potential therapeutic efficacy in a variety of human diseases, particularly epilepsy, Alzheimer's disease, and diabetes. Expand
Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity
In this review, the importance of novel galanin receptor–specific agonists and antagonists are emphasized, and new approaches, including new transgenic mouse lines (such as a recently characterized GAL3 knockout mouse) represent, in combination with viral-based techniques, critical tools required to better evaluate Galanin system physiology. Expand
No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis
- K. Bluemlein, Nana-Maria Grüning, R. Feichtinger, H. Lehrach, B. Kofler, M. Ralser
- Biology, Medicine
- 1 May 2011
The results reveal that an exchange in PKM1 to PKM2 isoform expression during cancer formation is not occurring, nor do these results support conclusions that PKM 2 is specific for proliferating, and PKM 1 for non-proliferating tissue. Expand
Loss of Complex I due to Mitochondrial DNA Mutations in Renal Oncocytoma
It is shown that loss of respiratory chain complex I (NADH/ubiquinone oxidoreductase) is associated with renal oncocytoma and that this deficiency is frequently caused by somatic mtDNA mutations. Expand
Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinoma.
The data indicate that a co-ordinated down-regulation of all components necessary for mitochondrial energy metabolism occurs in most renal carcinomas as an early event in carcinoma formation, which does not change with progression of the disease. Expand
Galanin receptor subtype GalR2 mediates apoptosis in SH-SY5Y neuroblastoma cells.
It is indicated that a high level of GalR 2 expression is able to inhibit cell proliferation and induce apoptosis in neuroblastoma cells and therefore identifies GalR2 as a possible target for pharmacological intervention in neuroblastic tumor biology. Expand
Mitochondria: The ketogenic diet--A metabolism-based therapy.
- Silvia Vidali, S. Aminzadeh, +4 authors R. Feichtinger
- Biology, Medicine
- The international journal of biochemistry & cell…
- 1 June 2015
As metabolic reprogramming from oxidative phosphorylation toward increased glycolysis is a hallmark of cancer cells; there is increasing evidence that the ketogenic diet may be beneficial as an adjuvant cancer therapy by potentiating the antitumor effect of chemotherapy and radiation treatment. Expand
The Mitochondrial T16189C Polymorphism Is Associated with Coronary Artery Disease in Middle European Populations
The results show for the first time a significant association of T16189C with CAD in a Middle European population, as reported in other studies, in patients with T2DM an association with T16 189C in individuals of European decent remains questionable. Expand
Pharmacological and functional characterization of galanin-like peptide fragments as potent galanin receptor agonists
Data suggest that the putative fragment GALP (3-32) might represent the strongest mediator of biological GALp activity and might be a useful tool to study the affinity of GALLP to galanin receptors and to search for specific G ALP receptors. Expand
Gangliocytes in neuroblastic tumors express alarin, a novel peptide derived by differential splicing of the galanin-like peptide gene
- Radmila Santic, Katrin Fenninger, +8 authors B. Kofler
- Biology, Medicine
- Journal of Molecular Neuroscience
The findings indicate that alarin expression is a feature of ganglionic differentiation in neuroblastic tumor tissues and reveals significant homology to other peptides. Expand