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Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
TLDR
It is reported that sphingosine-1-phosphate prevents the appearance of the key features of apoptosis, namely intranucleosomal DNA fragmentation and morphological changes, which result from increased concentrations of ceramide.
HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3.
TLDR
HDL is identified as a carrier of bioactive lysophospholipids that regulate vascular tone via S1P3-mediated NO release and induces vasodilation in isolated aortae via intracellular Ca2+ mobilization and Akt-mediated eNOS phosphorylation.
Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs
TLDR
Lowering ceramide abundance may be a central goal for the future development of antidepressants as the role of the acid sphingomyelinase-ceramide system as a target for antidepressants is investigated.
N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.
TLDR
DMS is a competitive inhibitor of sphingosine kinase from U937 monoblastic leukemia cells, Swiss 3T3 fibroblasts, and PC12 pheochromocytoma cells and is a useful tool to elucidate the role of SPP as an intracellular second messenger.
Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation.
TLDR
Genetic evidence is provided that deletion of CTSK in osteoclasts enhances bone formation in vivo by increasing the generation of osteoclast-derived S1P.
Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts
TLDR
It is shown that either ubiquitous or osteoclast-specific inactivation of the murine CT receptor (CTR) causes increased bone formation, and it is confirmed that S1P acts as an osteoanabolic molecule in vivo and provides evidence for a pharmacologically exploitable crosstalk between osteoclasts and osteoblasts.
Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice
TLDR
Composed exclusively of naturally occurring lipids, tailored liposomes are not bactericidal and could be used therapeutically either alone or in conjunction with antibiotics to combat bacterial infections and to minimize toxin-induced tissue damage that occurs during bacterial clearance.
Cyproterone Acetate Loading to Lipid Nanoparticles for Topical Acne Treatment: Particle Characterisation and Skin Uptake
TLDR
Topical CPA treatment of skin diseases should reduce side effects currently excluding the use in males and demanding contraceptive measures in females and may be an additional therapeutic option for acne and other diseases of the pilosebaceous unit.
Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype
TLDR
Data indicate that palmitate is metabolised by hepatocytes to S1P, which acts via stimulation of the S1p2 receptor to impair insulin signalling, which could be considered as a novel therapeutic target for the treatment of insulin resistance.
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