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The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand.
The action of 1 alpha, 25-dihydroxyvitamin D3 is mediated by its nuclear receptor (VDR), a ligand-dependent transcription regulator. We report the 1.8 A resolution crystal structure of the complexExpand
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Structure of the human 80S ribosome
Ribosomes are translational machineries that catalyse protein synthesis. Ribosome structures from various species are known at the atomic level, but obtaining the structure of the human ribosome hasExpand
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Conformational transition of initiation factor 2 from the GTP- to GDP-bound state visualized on the ribosome
Initiation of protein synthesis is a universally conserved event that requires initiation factors IF1, IF2 and IF3 in prokaryotes. IF2 is a GTPase essential for binding initiator transfer RNA to theExpand
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Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7
The non-coding RNA 7SK is the scaffold for a small nuclear ribonucleoprotein (7SKsnRNP) which regulates the function of the positive transcription elongation factor P-TEFb in the control of RNAExpand
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Structure of the 30S translation initiation complex
Translation initiation, the rate-limiting step of the universal process of protein synthesis, proceeds through sequential, tightly regulated steps. In bacteria, the correct messenger RNA start siteExpand
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Visualization of release factor 3 on the ribosome during termination of protein synthesis
Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the ribosome after release of theExpand
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A structural view of translation initiation in bacteria
Abstract.The assembly of the protein synthesis machinery occurs during translation initiation. In bacteria, this process involves the binding of messenger RNA(mRNA) start site and fMet-tRNAfMet toExpand
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New tools for the analysis and validation of cryo-EM maps and atomic models
New methods and PHENIX tools for quality assessment of cryo-EM maps, atomic models and model-to-map fitting are presented. Expand
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Structured mRNAs Regulate Translation Initiation by Binding to the Platform of the Ribosome
Gene expression can be regulated at the level of initiation of protein biosynthesis via structural elements present at the 5' untranslated region of mRNAs. These folded mRNA segments may bind to theExpand
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Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA
Transcription regulation by steroid hormones and other metabolites is mediated by nuclear receptors (NRs) such as the vitamin D and retinoid X receptors (VDR and RXR). Here, we present the cryoExpand
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