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Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer
- Yufei Wang, J. McKay, C. Amos
- BiologyNature Genetics
- 21 May 2014
TLDR
Genome-wide association studies of cancer: current insights and future perspectives
- A. Sud, B. Kinnersley, R. Houlston
- BiologyNature Reviews Cancer
- 13 October 2017
TLDR
Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer
- D. Chubb, P. Broderick, R. Houlston
- BiologyNature communications
- 22 June 2016
TLDR
Validation of Recently Proposed Colorectal Cancer Susceptibility Gene Variants in an Analysis of Families and Patients-a Systematic Review.
- P. Broderick, Sara E. Dobbins, R. Houlston
- Biology, MedicineGastroenterology
- 2017
TLDR
Genetic predisposition to mosaic Y chromosome loss in blood
- Deborah J. Thompson, G. Genovese, J. Perry
- Biology, MedicinebioRxiv
- 8 January 2019
TLDR
Germ line mutations in shelterin complex genes are associated with familial chronic lymphocytic leukemia.
- H. Speedy, B. Kinnersley, R. Houlston
- BiologyBlood
- 10 November 2016
Chronic lymphocytic leukemia (CLL) can be familial; however, thus far no rare germ line disruptive alleles for CLL have been identified. We performed whole-exome sequencing of 66 CLL families,…
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors
- B. Melin, J. Barnholtz-Sloan, M. Bondy
- BiologyNature Genetics
- 27 March 2017
TLDR
Genome-wide association study identifies multiple susceptibility loci for glioma
- B. Kinnersley, M. Labussière, R. Houlston
- BiologyNature communications
- 1 October 2015
TLDR
Genetic diagnosis of high-penetrance susceptibility for colorectal cancer (CRC) is achievable for a high proportion of familial CRC by exome sequencing.
- D. Chubb, P. Broderick, R. Houlston
- Medicine, BiologyJournal of clinical oncology : official journal…
- 5 January 2015
TLDR
Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk
- J. Vijayakrishnan, M. Qian, Jun J. Yang
- BiologyNature Communications
- 21 October 2019
There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B-ALL) we…
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