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HSP72 protects against obesity-induced insulin resistance
- Jason Chung, Anh-Khoi Nguyen, +15 authors M. Febbraio
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 5 February 2008
Patients with type 2 diabetes have reduced gene expression of heat shock protein (HSP) 72, which correlates with reduced insulin sensitivity. Heat therapy, which activates HSP72, improves clinical… Expand
Breaking Up Prolonged Sitting Reduces Postprandial Glucose and Insulin Responses
OBJECTIVE Observational studies show breaking up prolonged sitting has beneficial associations with cardiometabolic risk markers, but intervention studies are required to investigate causality. We… Expand
Arterial compliance increases after moderate-intensity cycling.
- B. Kingwell, K. Berry, J. Cameron, G. Jennings, A. Dart
- Biology, Medicine
- American journal of physiology. Heart and…
- 1 November 1997
Exercise training elevates arterial compliance at rest, but the effects of acute exercise in this regard are unknown. This study investigated the effects of a single, 30-min bout of cycling exercise… Expand
Pulse pressure--a review of mechanisms and clinical relevance.
The goal of this study was to review the origin, clinical relevance and treatment of pulse pressure (PP). Elevated PP is increasingly being recognized as a risk factor for cardiovascular,… Expand
HDL-targeted therapies: progress, failures and future
Since the discovery in the 1970s that plasma levels of high-density lipoprotein cholesterol (HDL-C) are inversely associated with cardiovascular outcome, it has been postulated that HDL is… Expand
Type 2 diabetic individuals have impaired leg blood flow responses to exercise: role of endothelium-dependent vasodilation.
- B. Kingwell, M. Formosa, M. Muhlmann, Scott J. Bradley, G. McConell
- Diabetes care
- 1 March 2003
OBJECTIVE Diabetic individuals have impaired endothelium-dependent forearm vasodilatory responses to ischemia, acetylcholine, and other endothelium-dependent agonists. The functional significance of… Expand
Variations in endothelial function and arterial compliance during the menstrual cycle.
- M. Williams, R. Westerman, +4 authors P. Komesaroff
- The Journal of clinical endocrinology and…
- 1 November 2001
Female sex hormones have been implicated in the cardioprotection of premenopausal women. However, the cardiovascular actions of these hormones and the effects of their natural fluctuations during the… Expand
Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance
Dysregulated lipid metabolism and inflammation are linked to the development of insulin resistance in obesity, and the intracellular accumulation of the sphingolipid ceramide has been implicated in… Expand
Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism.
Liver steatosis is associated with the development of insulin resistance and the pathogenesis of type 2 diabetes. We tested the hypothesis that protein signals originating from steatotic hepatocytes… Expand
Heart Rate Spectral Analysis, Cardiac Norepinephrine Spillover, and Muscle Sympathetic Nerve Activity During Human Sympathetic Nervous Activation and Failure
- B. Kingwell, J. Thompson, D. Kaye, G. McPherson, G. Jennings, M. Esler
- 1 July 1994
Although heart rate variability (HRV) at 0.1 Hz has been proposed as a noninvasive clinical measure of cardiac sympathetic nerve firing, this premise has not been sufficiently validated by comparison… Expand