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Breaking Up Prolonged Sitting Reduces Postprandial Glucose and Insulin Responses
TLDR
Interrupting sitting time with short bouts of light- or moderate-intensity walking lowers postprandial glucose and insulin levels in overweight/obese adults and may improve glucose metabolism and potentially be an important public health and clinical intervention strategy for reducing cardiovascular risk. Expand
HSP72 protects against obesity-induced insulin resistance
TLDR
An essential role is identified for HSP72 in blocking inflammation and preventing insulin resistance in the context of genetic obesity or high-fat feeding and protection against diet- or obesity-induced hyperglycemia, hyperinsulinemia, glucose intolerance, and insulin resistance. Expand
Arterial compliance increases after moderate-intensity cycling.
TLDR
Investigating the effects of a single, 30-min bout of cycling exercise at 65% of maximal oxygen consumption on indexes of arterial compliance found whole body arterial Compliance was elevated by mechanisms that may relate to vasodilation. Expand
Pulse pressure--a review of mechanisms and clinical relevance.
TLDR
The origin, clinical relevance and treatment of pulse pressure is reviewed, and a distributed compliance model of the arterial circulation provides a framework for understanding the causes, effects and potential treatment of elevations in PP. Expand
HDL-targeted therapies: progress, failures and future
TLDR
The HDL hypothesis is examined in molecular and mechanistic terms, focusing on features that have been addressed, those that remain to be tested, and potential new targets for future pharmacological interventions. Expand
Type 2 diabetic individuals have impaired leg blood flow responses to exercise: role of endothelium-dependent vasodilation.
TLDR
The increase in LBF during exercise is substantially attenuated in type 2 diabetic compared with matched control subjects, and this mechanism may be of importance in determining the leg ischemic threshold in diabetic individuals with peripheral vascular disease. Expand
Heart Rate Spectral Analysis, Cardiac Norepinephrine Spillover, and Muscle Sympathetic Nerve Activity During Human Sympathetic Nervous Activation and Failure
TLDR
HRV at 0.1 Hz depends on factors in addition to cardiac sympathetic nerve firing rates, including multiple neural reflexes, cardiac adrenergic receptor sensitivity, postsynaptic signal transduction, and electrochemical coupling, and is not directly related to cardiac norepinephrine spillover, which is a more direct measure of the sympathetic nerve fired rate. Expand
Variations in endothelial function and arterial compliance during the menstrual cycle.
TLDR
The importance of menstrual phase in the interpretation of data on endothelial function is emphasized and may provide insights into the mechanisms underlying sex differences in cardiovascular risk and other disease processes in premenopausal women. Expand
Muscular strength training is associated with low arterial compliance and high pulse pressure.
TLDR
The data indicate that both the proximal aorta and the leg arteries are stiffer in strength-trained individuals and contribute to a higher cardiac afterload. Expand
Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance
TLDR
The newly identified roles of LDL-ceramide suggest that strategies aimed at reducing hepatic ceramide production or reducing ceramide packaging into lipoproteins may improve skeletal muscle insulin action. Expand
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