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Levels of angiotensin and molecular biology of the tissue renin angiotensin systems
The evidence that is lacking for a paracrine function of angiotensin is a complete description of the intracellular molecular synthesis and release of Ang II from single cells of promising tissues. Expand
Attenuation of Hypertension and Heart Hypertrophy by Adeno-Associated Virus Delivering Angiotensinogen Antisense
It is concluded that rAAV-AGT-AS offers a safe, stable approach for gene therapy of hypertension and significantly attenuated hypertension in adulthood for up to 6 months. Expand
Converting enzyme inhibitors and brain angiotensin.
The results showed an increase of brain ANG II in normotensive animals with angiotensin converting enzyme inhibitor but a reduction of brainstem ANGII in the SHR, which may indicate the mechanism of lowering blood pressure in SHR is by disinhibition of the baroreflex. Expand
Brain angiotensin in the developing spontaneously hypertensive rat.
The higher levels of brain Ang II inSHR support the hypothesis that hypertension in SHR is related to brain angiotensin II activity and demonstrate changes inbrain Ang II with development. Expand
Changes in skin angiotensin II receptors in rats during wound healing.
- B. Kimura, C. Sumners, M. Phillips
- Biology, Medicine
- Biochemical and biophysical research…
- 16 September 1992
It is demonstrated that adult rat skin contains predominantly AT1 receptors and also that these receptors are downregulated for 12-24 hours after wounding. Expand
Atrial natriuretic peptide as a marker for doxorubicin‐induced cardiotoxic effects
- Martin Bauch, Alice Ester, B. Kimura, B. Victorica, A. Kedar, M. Ian Phillips
- 15 March 1992
Preliminary results suggest that pANP may be useful as an early and sensitive indicator for doxorubicin‐related myocardial damage. Expand
Losartan potassium, a nonpeptide antagonist of angiotensin II, chronically administered p.o. does not readily cross the blood-brain barrier.
It is concluded that losartan potassium does not readily cross the blood-brain barrier using this dose regimen, which was carried out using conscious normotensive Sprague-Dawley rats. Expand
Prolonged reduction of high blood pressure with an in vivo, nonpathogenic, adeno-associated viral vector delivery of AT1-R mRNA antisense.
The results suggest that a prolonged reduction in high blood pressure can be achieved with AAV vectors delivering antisense to inhibit AT1 receptors with a single administration. Expand
Reduction of cold-induced hypertension by antisense oligodeoxynucleotides to angiotensinogen mRNA and AT1-receptor mRNA in brain and blood.
Data show that AS-ODN reduces BP in cold-induced hypertension and that the hypertension involves both peripheral tissues and central RAS in addition to blood-borne RAS mechanisms. Expand
Critical role of AT1 receptor expression after ischemia/reperfusion in isolated rat hearts: beneficial effect of antisense oligodeoxynucleotides directed at AT1 receptor mRNA.
A critical role of AT1R upregulation in determining myocardial function immediately after ischemia/reperfusion is implied and AS-ODNs to At1R mRNA may be more beneficial thanLosartan, because losartan does not affect the plasma angiotensin II level. Expand