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The influence of dose, time of administration, body temperature and salicylate kinetics on the antithrombotic action of acetylsalicylic acid in male rats.
TLDR
Serum salicylate studies did not support the view that loss of protection was due to competition between salicYLate and ASA for cyclooxygenase-binding sites, but ASA was also protective at 200 mg/kg i.v., possibly through non-specific toxic effects. Expand
Structure-activity studies of aspirin and related compounds on platelet aggregation, arachidonic acid metabolism in platelets and artery, and arterial prostacyclin activity.
TLDR
A cyclical derivative, 3-methylphthalide (3-MP), inhibited both platelet function and PGI2 synthesis although it did not inhibit cyclo-oxygenase activity, suggesting a novel mechanism of action. Expand
The use and safety of Ibuprofen in the hemophiliac.
TLDR
Ibuprofen should be considered as a safe and potentially beneficial antiinflammatory agent in the treatment of carefully monitored hemophiliacs eligible for such therapy. Expand
Neutrophil-mediated increased permeability of microcarrier-cultured endothelial monolayers: a model for the in vitro study of neutrophil-dependent mediators of vasopermeability.
TLDR
The microcarrier-cultured human endothelial monolayer system rapidly detects permeability alterations of endothelium-covered microcarriers in response to activated human neutrophils and this model is a potentially useful screening assay for the development of therapeutic agents, directed at neutrophil de granulation or degranulation products, for the control of inflammatory vasopermeability abnormalities. Expand
The use and safety of Ibuprofen in the hemophiliac.
TLDR
Ibuprofen should be considered as a safe and potentially beneficial antiinflammatory agent in the treatment of carefully monitored hemophiliacs eligible for such therapy. Expand
Antiinflammatory properties of a hydroperoxide compound, structurally related to acetylsalicylic acid
TLDR
3-Hydroperoxy-3-methylphthalide, a structural analog of acetylsalicylic acid, was found to have some antiinflammatory properties which are distinct from those of ASA. Expand
The effects of some benzoic acid derivatives on polymorphonuclear leukocyte accumulation in vivo.
TLDR
It is indicated that drug effects on PMN leukocyte accumulation is an important determinant of anti-inflammatory potential. Expand
Orthopaedics and Haemophilia
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