Share This Author
The influence of dose, time of administration, body temperature and salicylate kinetics on the antithrombotic action of acetylsalicylic acid in male rats.
Serum salicylate studies did not support the view that loss of protection was due to competition between salicYLate and ASA for cyclooxygenase-binding sites, but ASA was also protective at 200 mg/kg i.v., possibly through non-specific toxic effects.
The use and safety of Ibuprofen in the hemophiliac.
Ibuprofen should be considered as a safe and potentially beneficial antiinflammatory agent in the treatment of carefully monitored hemophiliacs eligible for such therapy.
Structure-activity studies of aspirin and related compounds on platelet aggregation, arachidonic acid metabolism in platelets and artery, and arterial prostacyclin activity.
Neutrophil-mediated increased permeability of microcarrier-cultured endothelial monolayers: a model for the in vitro study of neutrophil-dependent mediators of vasopermeability.
- J. Killackey, B. Killackey
- Biology, MedicineCanadian journal of physiology and pharmacology
- 1 July 1990
The microcarrier-cultured human endothelial monolayer system rapidly detects permeability alterations of endothelium-covered microcarriers in response to activated human neutrophils and this model is a potentially useful screening assay for the development of therapeutic agents, directed at neutrophil de granulation or degranulation products, for the control of inflammatory vasopermeability abnormalities.
The effects of a hydroperoxide compound, structurally related to ASA, on arachidonic acid metabolism by various tissues and PMN accumulation in an in vivo model
Antiinflammatory properties of a hydroperoxide compound, structurally related to acetylsalicylic acid
3-Hydroperoxy-3-methylphthalide, a structural analog of acetylsalicylic acid, was found to have some antiinflammatory properties which are distinct from those of ASA.
The effects of some benzoic acid derivatives on polymorphonuclear leukocyte accumulation in vivo.
The Safety Of Ibuprofen In Factor VIII And IX Deficient Hemophiliacs
Orthopaedics and Haemophilia