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- Publications
- Influence
Gallium in cancer treatment.
- P. Collery, B. Keppler, C. Madoulet, B. Desoize
- Medicine
- Critical reviews in oncology/hematology
- 1 June 2002
Gallium (Ga) is the second metal ion, after platinum, to be used in cancer treatment. Its activities are numerous and various. It modifies three-dimensional structure of DNA and inhibits its… Expand
Antitumour metal compounds: more than theme and variations.
- M. Jakupec, M. Galanski, V. Arion, C. Hartinger, B. Keppler
- Chemistry, Medicine
- Dalton transactions
- 14 January 2008
Triggered by the resounding success of cisplatin, the past decades have seen tremendous efforts to produce clinically beneficial analogues. The recent achievement of oxaliplatin for the treatment of… Expand
Tumour-inhibiting platinum complexes--state of the art and future perspectives.
- M. Jakupec, M. Galanski, B. Keppler
- Chemistry, Medicine
- Reviews of physiology, biochemistry and…
- 2003
Thirty years after the onset of the first clinical studies with cisplatin, the development of antineoplastic platinum drugs continues to be a productive field of research. This article reviews the… Expand
From bench to bedside--preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A).
- C. Hartinger, Stefanie Zorbas-Seifried, M. Jakupec, B. Kynast, H. Zorbas, B. Keppler
- Chemistry, Medicine
- Journal of inorganic biochemistry
- 1 May 2006
Indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A) is just the second ruthenium-based anticancer agent after NAMI-A which was developed to the stage of clinical trials.… Expand
Relevance of peat-draining rivers for the riverine input of dissolved iron into the ocean.
- R. Krachler, R. Krachler, +5 authors B. Keppler
- Geology, Medicine
- The Science of the total environment
- 1 May 2010
Peat bogs have the ability to produce strong chelate ligands (humic and fulvic acids) which enhance the weathering rates of iron-silicate minerals and greatly increase the solubility of the essential… Expand
Metal complexes in cancer chemotherapy
- B. Keppler
- Chemistry
- 1993
Metal complexes in cancer chemotherapy - general remarks, B.K. Keppler platinum an dnon-platinum complexes in clinical trials, M.E. Hein provisions for international approval of metal complexes in… Expand
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KP1019, A New Redox‐Active Anticancer Agent – Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients
- C. Hartinger, M. Jakupec, +6 authors B. Keppler
- Chemistry, Medicine
- Chemistry & biodiversity
- 1 October 2008
The promising drug candidate indazolium trans‐[tetrachlorobis(1H‐indazole)ruthenate(III)] (KP1019) is the second Ru‐based anticancer agent to enter clinical trials. In this review, which is an update… Expand
NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application
- Robert Trondl, P. Heffeter, C. Kowol, M. Jakupec, W. Berger, B. Keppler
- Chemistry
- 30 June 2014
NKP-1339 is the first-in-class ruthenium-based anticancer drug in clinical development against solid cancer and has recently been studied successfully in a phase I clinical trial. Ruthenium compounds… Expand
Update of the preclinical situation of anticancer platinum complexes: novel design strategies and innovative analytical approaches.
- M. Galanski, M. Jakupec, B. Keppler
- Chemistry, Medicine
- Current medicinal chemistry
- 31 July 2005
Research in the field of bioinorganic chemistry has been stimulated by the worldwide success of the anticancer drug cisplatin. 40 years after the first report about its biological activity,… Expand
Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation.
- C. Kowol, Robert Trondl, +6 authors B. Keppler
- Chemistry, Medicine
- Journal of medicinal chemistry
- 28 July 2009
The first metal complexes of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (Triapine) were synthesized. Triapine was prepared by a novel three-step procedure in 64% overall yield. In addition, a… Expand