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cDNA cloning of biologically active chicken interleukin-18.
By searching a chicken EST database, we identified a cDNA clone that appeared to contain the entire open reading frame (ORF) of chicken interleukin-18 (ChIL-18). The encoded protein consists of 198Expand
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A chicken homolog of mammalian interleukin-1 beta: cDNA cloning and purification of active recombinant protein.
Upon induction with lipopolysaccharide (LPS) the chicken macrophage cell line HD-11 secretes an activity that stimulates the synthesis of a CXC chemokine in the chicken fibroblast cell line CEC-32.Expand
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Chicken interleukin-6. cDNA structure and biological properties.
Suppression subtractive hybridization technology was used to identify differentially expressed genes in spleens of chickens that had been treated with the synthetic immune modifier S-28463. OneExpand
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Broad Tissue and Cell Tropism of Avian Bornavirus in Parrots with Proventricular Dilatation Disease
ABSTRACT Avian bornaviruses (ABV), representing a new genus within the family Bornaviridae, were recently discovered in parrots from North America and Israel with proventricular dilatation diseaseExpand
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Cytokines of birds: conserved functions--a largely different look.
Targeted disruptions of the mouse genes for cytokines, cytokine receptors, or components of cytokine signaling cascades convincingly revealed the important roles of these molecules in immunologicExpand
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Use of C-reactive protein to predict outcome in dogs with systemic inflammatory response syndrome or sepsis.
BACKGROUND There is a high mortality rate in patients with systemic inflammatory response syndrome (SIRS) or sepsis. Therefore, an early diagnosis and prognostic assessment is important for optimalExpand
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NK and T cells constitute two major, functionally distinct intestinal epithelial lymphocyte subsets in the chicken.
Non-mammalian NK cells have not been characterized in detail; however, their analysis is essential for the understanding of the NK cell receptor phylogeny. As a first step towards defining chicken NKExpand
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Chicken BAFF--a highly conserved cytokine that mediates B cell survival.
Members of the tumor necrosis factor (TNF) family play key roles in the regulation of inflammation, immune responses and tissue homeostasis. Here we describe the identification of the chickenExpand
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IL-18 Stimulates the Proliferation and IFN-γ Release of CD4+ T Cells in the Chicken: Conservation of a Th1-Like System in a Nonmammalian Species1
The phylogeny of Th1 and Th2 subsets has not been characterized mainly due to the limited information regarding cytokines in nonmammalian vertebrates. In this study, we characterize a Th1-likeExpand
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Immunoglobulin knockout chickens via efficient homologous recombination in primordial germ cells
Significance Chickens have been an important animal model in the fields of developmental biology and immunology over the last century and have contributed a number of basic findings in these areas.Expand
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