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Id proteins: small molecules, mighty regulators.
TLDR
The current understanding of the function of Id proteins is highlighted and gaps in knowledge about the mechanisms whereby Id proteins exert their diverse effects in multiple cellular processes are discussed. Expand
Evaluation of p38 MAPK pathway as a molecular signature in ulcerative colitis.
TLDR
Results indicate that molecular signature of P38 MAPK pathway might be a potential biomarker for evaluating UC risk and classified UC risk with high sensitivity and specificity. Expand
Expression of programmed cell death 5 gene involves in regulation of apoptosis in gastric tumor cells
TLDR
Observations lay down a reasonable postulation that PDCD5 may play a key role to regulate the apoptotic processes in the GC cells and gastric tumors. Expand
Gastrokine 1 induces senescence through p16/Rb pathway activation in gastric cancer cells
TLDR
It was shown that GKN1 is an autocrine/paracrine protein and inhibits cell growth due to senescence, which resulted from activation of p16/Rb and p21waf pathways, and indicates that G KN1 might be a potential novel target for gastric cancer therapeutics. Expand
Expression status of ataxia-telangiectasia-mutated gene correlated with prognosis in advanced gastric cancer.
TLDR
In a cohort of 70 GC samples, low level of phosphorylated ATM was significantly correlated with poor differentiation, lymph node metastasis and poor 5-year survival, indicating that ATM phosphorylation status might be a prognostic marker for individual therapy in advanced GC patients. Expand
Comparative analysis of the protein profiles from primary gastric tumors and their adjacent regions: MAWBP could be a new protein candidate involved in gastric cancer.
TLDR
MAWBP could be a new GC-related protein even though its physiological roles remain unexplored, on the basis of the proteomic strategy developed in the laboratory. Expand
Evaluation of hepatic-metastasis risk of colorectal cancer upon the protein signature of PI3K/AKT pathway.
TLDR
The protein signature derived from PI3K/AKT pathway is likely a promising multiplex biomarker for HM of colorectal cancer patients with/without HM. Expand
MFAP3L activation promotes colorectal cancer cell invasion and metastasis.
TLDR
It is experimentally demonstrated for the first time that MFAP3L likely participates in the nuclear signaling of EGFR and ERK2 and acts as a novel nuclear kinase that impacts CRC metastasis. Expand
Regulation of cancer stem cells by RING finger ubiquitin ligases.
TLDR
This review summarizes current knowledge in the research field of ubiquitin modification system and identifies many RING finger E3s that are implicated in the positive and negative regulation of CSC maintenance. Expand
Interleukin-37 gene variants segregated anciently coexist during hominid evolution
IL37 is a member of IL-1 cytokine family but conveys anti-inflammatory functions. The biological characteristic and genetic heterogeneity of IL37 are not fully understood yet. Here using theExpand
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