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Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron.
DCT2 and CNT are disclosed as major sites for transcellular Ca(2+) transport in the mouse distal nephron, which suggests their mutual interactions in transport regulation. Expand
Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb.
NHE-3 is the isoform responsible for NaCl and NaHCO3 absorption in the proximal convoluted tubule, and NahCO absorption in a thick ascending limb and apical membrane Na/H exchange activity is likely mediated by other isoform of the NHE family. Expand
Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK.
It is shown by real-time RT-PCR and immunofluorescence that an aldosterone injection in adrenalectomized rats induces alpha-ENaC subunit expression along the entire ASDN within 2 h, whereas beta- and gamma- ENaC are constitutively expressed. Expand
Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells.
In conclusion, overexpression of TGF-beta1 in renal tubules in vivo induces interstitial proliferation, tubular autophagy, and fibrosis, but not epithelial-to-mesenchymal transition. Expand
Altered renal distal tubule structure and renal Na(+) and Ca(2+) handling in a mouse model for Gitelman's syndrome.
Loss of NCC leads to major structural remodeling of the renal distal tubule that goes along with marked changes in glomerular and tubular function, which may explain some of the clinical features of Gitelman's syndrome. Expand
Structural analysis of the rabbit kidney.
  • B. Kaissling, W. Kriz
  • Chemistry, Medicine
  • Advances in anatomy, embryology, and cell biology
  • 13 March 1979
Organization of the pronephric kidney revealed by large-scale gene expression mapping
The present study validates the Xenopus pronephros as a genuine model that may be used to elucidate the molecular basis of nephron segmentation and human renal disease and proposes a new nomenclature, in line with the mammalian one. Expand
Expression of Na-P(i) cotransport in rat kidney: localization by RT-PCR and immunohistochemistry.
The described distribution of the NaP(i)-2 protein is in agreement with previously described nephron sites of P(i) reabsorption in the rat kidney and therefore suggests that the NaF(i-2) transport system represents an Na-P( i) cotransporter involved in proximal tubular apical transport of phosphate. Expand
Localization of organic cation transporters OCT1 and OCT2 in rat kidney.
The data suggest that rO CT1 and rOCT2 are responsible for basolateral cation uptake in the proximal tubule, which represents the first step in cation secretion. Expand
Differential subcellular localization of ENaC subunits in mouse kidney in response to high- and low-Na diets.
The data on mice adapted to moderately low and high Na intake suggest that regulation of ENaC function in vivo involves shifts of beta- and gamma-subunits from the cytoplasm to the apical plasma membrane and vice versa, respectively. Expand