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Redox regulation of protein tyrosine phosphatase 1B (PTP1B): a biomimetic study on the unexpected formation of a sulfenyl amide intermediate.
The effect of steric and electronic environments around the sulfur and nitrogen atoms and the role of nonbonded S...O/N interactions on the cyclization reactions of amide substituted benzene sulfenicExpand
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Selenium-containing enzymes in mammals: Chemical perspectives
The chemical and biochemical route to the synthesis of the 21st amino acid in living systems, selenocysteine, is described. The incorporation of this rare amino acid residue into proteins isExpand
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Glutathione peroxidase (GPx)-like antioxidant activity of the organoselenium drug ebselen: unexpected complications with thiol exchange reactions.
The factors that are responsible for the relatively low glutathione peroxidase (GPx)-like antioxidant activity of organoselenium compounds such as ebselen (1, 2-phenyl-1,2-benzisoselenazol-3(2H)-one)Expand
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Antioxidant activity of the anti-inflammatory compound ebselen: a reversible cyclization pathway via selenenic and seleninic acid intermediates.
A revised mechanism that accounts for the glutathione peroxidase (GPx)-like catalytic activity of the organoselenium compound ebselen is described. It is shown that the reaction of ebselen withExpand
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Synthesis, structure, spirocyclization mechanism, and glutathione peroxidase-like antioxidant activity of stable spirodiazaselenurane and spirodiazatellurane.
The first examples of stable spirodiazaselenurane and spirodiazatellurane were synthesized by oxidative spirocyclization of the corresponding diaryl selenide and telluride and were structurallyExpand
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Thiol cofactors for selenoenzymes and their synthetic mimics.
The importance of selenium as an essential trace element is now well recognized. In proteins, the redox-active selenium moiety is incorporated as selenocysteine (Sec), the 21st amino acid. InExpand
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Submonomer synthesis of a hybrid peptoid-azapeptoid library.
We recently reported efficient conditions for the synthesis of N-azapeptoid libraries via the typical submonomer strategy of peptoid synthesis but that substitutes N-acyl hydrazides for primaryExpand
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Acyl hydrazides as peptoid sub-monomers.
The use of acyl hydrazides as peptoid sub-monomers is investigated. We demonstrate here that azapeptoids derived entirely from acyl hydrazides can be made conveniently and efficiently using standardExpand
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Theoretical investigation on the effect of different nitrogen donors on intramolecular Se...N interactions.
  • B. K. Sarma, G. Mugesh
  • Chemistry, Medicine
  • Chemphyschem : a European journal of chemical…
  • 7 December 2009
The effect of different donor nitrogen atoms on the strength and nature of intramolecular Se...N interactions is evaluated for organoselenium compounds having N,N-dimethylaminomethyl (dime),Expand
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Reciprocal carbonyl–carbonyl interactions in small molecules and proteins
Carbonyl-carbonyl n→π* interactions where a lone pair (n) of the oxygen atom of a carbonyl group is delocalized over the π* orbital of a nearby carbonyl group have attracted a lot of attention inExpand
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