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Ethnobotanical-directed discovery of the antihyperglycemic properties of cryptolepine: its isolation from Cryptolepis sanguinolenta, synthesis, and in vitro and in vivo activities.
- D. Bierer, D. M. Fort, +15 authors S. R. King
- Chemistry, Medicine
- Journal of medicinal chemistry
- 24 February 1998
Using an ethnobotanical approach in combination with in vivo-guided fractionation as a means for lead discovery, cryptolepine was isolated as an antihyperglycemic component of Cryptolepis… Expand
Studies on cryptolepine. II: Inhibition of carrageenan induced oedema by cryptolepine.
Muscle relaxant properties of aqueous extract of Lippia multiflora.
Aqueous leaf extracts of LIPPIA MULTIFLORA administered intraperitoneally produced a profound calming effect, muscle relaxing action, and significant reduction in the spontaneous locomotor activity… Expand
Cryptolepine inhibits platelet aggregation in vitro and in vivo and stimulates fibrinolysis ex vivo
Abstract 1. 1. Cryptolepine—the methylquindolanol alkaloid of Cryptolepsis sanguinolenta was evaluated for its antiplatelet and fibrinolytic effects. 2. 2. It exhibited antiplatelet effects in vitro… Expand
Cryptolepis sanguinolenta: an ethnobotanical approach to drug discovery and the isolation of a potentially useful new antihyperglycaemic agent
- J. Luo, D. M. Fort, +12 authors G. Reaven
- Diabetic medicine : a journal of the British…
- 1 May 1998
Evidence has been published that a wide array of plant‐derived active principles, representing numerous classes of chemical compounds, demonstrate activity consistent with their possible use in the… Expand
The alpha-adrenoceptor blocking properties of cryptolepine on the rat isolated vas deferens. Studies on cryptolepine.
Studies on cryptolepine.
The inhibitory effects of cryptolepine and its interaction with prostaglandin E (2), indomethacin, adrenaline and acetylcholine have been investigated on the isolated rabbit duodenum. Cryptolepine… Expand
Preferential blockade of pre-synaptic alpha-adrenoceptors on the rat isolated vas deferens by cryptolepine, 7:studies on cryptolepine.
The twitch response of the rat isolated vas deferens to electrical field stimulation, (1 to 10 Hz, 1 to 2 m. sec.), reduced by noradrenaline (1 to 2 μg ml -1 ) was further enhanced by cryptolepine (5… Expand
The vascular actions of aqueous extract of Lippia multiflora.
Intravenously administered aqueous leaf extract (6.3 to 12.5 mg/kg) in anaesthetised cats and (3.2 to 6.3 mg/kg) in anaesthetised rats, produced a significant fall (P < 0.05, n = 10) in the mean,… Expand
Antiulcerative properties and acute toxicity profile of some African medicinal plant extracts.
- B. K. Noamesi, J. Mensah, M. Bogale, E. Dagne, J. Adotey
- Journal of ethnopharmacology
- 1 March 1994
The aqueous extract of the stem bark of Tetrapleura tetraptera Schum et Thonn., Guibourtia ehie Leonard and the root extract of Taverniera abyssinica A. Rich. were used for the treatment of… Expand