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Ethnobotanical-directed discovery of the antihyperglycemic properties of cryptolepine: its isolation from Cryptolepis sanguinolenta, synthesis, and in vitro and in vivo activities.
Using an ethnobotanical approach in combination with in vivo-guided fractionation as a means for lead discovery, cryptolepine was isolated as an antihyperglycemic component of CryptolepisExpand
Muscle relaxant properties of aqueous extract of Lippia multiflora.
Aqueous leaf extracts of LIPPIA MULTIFLORA administered intraperitoneally produced a profound calming effect, muscle relaxing action, and significant reduction in the spontaneous locomotor activityExpand
Cryptolepine inhibits platelet aggregation in vitro and in vivo and stimulates fibrinolysis ex vivo
Abstract 1. 1. Cryptolepine—the methylquindolanol alkaloid of Cryptolepsis sanguinolenta was evaluated for its antiplatelet and fibrinolytic effects. 2. 2. It exhibited antiplatelet effects in vitroExpand
Cryptolepis sanguinolenta: an ethnobotanical approach to drug discovery and the isolation of a potentially useful new antihyperglycaemic agent
Evidence has been published that a wide array of plant‐derived active principles, representing numerous classes of chemical compounds, demonstrate activity consistent with their possible use in theExpand
Studies on cryptolepine.
The inhibitory effects of cryptolepine and its interaction with prostaglandin E (2), indomethacin, adrenaline and acetylcholine have been investigated on the isolated rabbit duodenum. CryptolepineExpand
Preferential blockade of pre-synaptic alpha-adrenoceptors on the rat isolated vas deferens by cryptolepine, 7:studies on cryptolepine.
The twitch response of the rat isolated vas deferens to electrical field stimulation, (1 to 10 Hz, 1 to 2 m. sec.), reduced by noradrenaline (1 to 2 μg ml -1 ) was further enhanced by cryptolepine (5Expand
The vascular actions of aqueous extract of Lippia multiflora.
Intravenously administered aqueous leaf extract (6.3 to 12.5 mg/kg) in anaesthetised cats and (3.2 to 6.3 mg/kg) in anaesthetised rats, produced a significant fall (P < 0.05, n = 10) in the mean,Expand
Antiulcerative properties and acute toxicity profile of some African medicinal plant extracts.
The aqueous extract of the stem bark of Tetrapleura tetraptera Schum et Thonn., Guibourtia ehie Leonard and the root extract of Taverniera abyssinica A. Rich. were used for the treatment ofExpand