• Publications
  • Influence
Sodium and angiotensin in hypertension induced by long-term nitric oxide blockade.
The influence of dietary sodium restriction and angiotensin II blockade on hypertension induced by a 25-day period of administration of the inhibitor of nitric oxide synthesisExpand
Nitric oxide pathway counteracts enhanced contraction to membrane depolarization in aortic rings of rats on high-sodium diet.
Evidence is provided that response of vascular smooth muscle cell to nitric oxide/cGMP-related compounds is increased in HS rings and is associated with a greater activation of the repolarizing BK(Ca) channels. Expand
Nitric oxide participates in the renal vasodilatory effect of candesartan in anesthetized rats.
The loss of renal vasodilatory effect of candesartan during L-NAME infusion suggests that AT1 receptor blockade is associated with an increase in nitric oxide-dependent tone, which participates in the full expression of the renal vasODilatory action of AngII type-1 receptors blockade in anesthetized normotensive rats. Expand
Simvastatin Prevents Angiotensin II–Induced Cardiac Alteration and Oxidative Stress
Results indicate that simvastatin prevented the development of hypertension and cardiovascular hypertrophy together with inhibition of the induced angiotensin II production of ROS. Expand
Prevention of the cardiovascular and renal effects of angiotensin II by endothelin blockade.
In conclusion, endogenous endothelin contributes to the cardiovascular and renal effects of Ang II, and the dipsogenic action of angiotensin II was not influenced by bosentan. Expand
Sodium restriction prevents cardiac hypertrophy and oxidative stress in angiotensin II hypertension.
The beneficial influence of dietary sodium restriction on target organ damage induced by angiotensin II is independent of arterial pressure reduction and possibly related to attenuation of the prooxidant effect of the peptide. Expand
Blood pressure variability in established L-NAME hypertension in rats.
The sympathetic nervous system seems to be a major determinant of the increased short-term variability of arterial pressure in this model, and nitric oxide participates in the control of arterIAL pressure variability. Expand
Dietary sodium restriction prevents kidney damage in high fructose-fed rats.
Dietary salt depletion has beneficial effects on renal and metabolic alterations associated with a high-fructose diet in rats and a prevention of histologic changes in retroperitoneal fat induced by high fructose. Expand
Haemodynamic and heart rate reflex responses to propofol in the rabbit. Comparison with althesin.
The relative preservation of baroreceptor reflex responses, and the reduction in TPR by a reduction of resting constrictor tone, suggest propofol may have significant clinical advantages when used as a sedative infusion. Expand
Simvastatin Reverses Target Organ Damage and Oxidative Stress in Angiotensin II Hypertension: Comparison With Apocynin, Tempol, and Hydralazine
Results indicate that simvastatin reverse established cardiac and renal alterations in AngII hypertension independently of arterial pressure, and it is suggested that oxidative stress participates in the maintenance of target organ damage and that antioxidant properties are involved in the beneficial influence of the statin. Expand