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Arcanobacterium pyogenes: molecular pathogenesis of an animal opportunist
Arcanobacterium pyogenes is a commensal and an opportunistic pathogen of economically important livestock, causing diseases as diverse as mastitis, liver abscessation and pneumonia. This organismExpand
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Prevalence of cpb2, encoding beta2 toxin, in Clostridium perfringens field isolates: correlation of genotype with phenotype.
Beta2 toxin, encoded by the cpb2 gene, has been implicated in the pathogenesis of porcine, equine and bovine enteritis by type A Clostridium perfringens. By incorporating primers to cpb2 into aExpand
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Atypical cpb2 Genes, Encoding Beta2-Toxin in Clostridium perfringens Isolates of Nonporcine Origin
ABSTRACT Beta2-toxin, encoded by cpb2, is implicated in the pathogenesis of Clostridium perfringens enteritis. However, cpb2 genes from nonporcine C. perfringens isolates were not always expressed,Expand
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Characterization of Campylobacter jejuni Biofilms under Defined Growth Conditions
ABSTRACT Campylobacter jejuni is a major cause of human diarrheal disease in many industrialized countries and is a source of public health and economic burden. C. jejuni, present as normal flora inExpand
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Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens.
Clostridium perfringens is a Gram-positive, anaerobic spore-forming bacterium commonly found in soil, sediments, and the human gastrointestinal tract. C. perfringens is responsible for a wideExpand
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Clonal relationships among Clostridium perfringens of porcine origin as determined by multilocus sequence typing.
Clostridium perfringens is ubiquitous in the environment and the intestinal tracts of most mammals, but this organism also causes gas gangrene and enteritis in human and animal hosts. WhileExpand
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Clostridium perfringens Beta-Toxin Forms Potential-Dependent, Cation-Selective Channels in Lipid Bilayers
ABSTRACT Recombinant beta-toxin from Clostridium perfringenstype C was found to increase the conductance of bilayer lipid membranes (BLMs) by inducing channel activity. The channels exhibited aExpand
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Identification and role in virulence of putative iron acquisition genes from Corynebacterium pseudotuberculosis.
Four genes, fagA, B, C and D, encoding products with 32-47% identity to proteins involved in bacterial iron uptake systems, were identified immediately downstream of the CorynebacteriumExpand
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An Arcanobacterium (Actinomyces) pyogenes mutant deficient in production of the pore-forming cytolysin pyolysin has reduced virulence.
Pyolysin (PLO), the hemolytic exotoxin expressed by Arcanobacterium (Actinomyces) pyogenes, is a member of the thiol-activated cytolysin family of bacterial toxins. Insertional inactivation of theExpand
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Thiol-activated cytolysins: structure, function and role in pathogenesis.
Members of the thiol-activated family of cytolysins are involved in the mechanism of pathogenesis of a number of Gram-positive species. While they are pore-forming toxins, their major pathogenicExpand
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