• Publications
  • Influence
Escherichia coli sequence type ST131 as the major cause of serious multidrug-resistant E. coli infections in the United States.
BACKGROUND Escherichia coli sequence type ST131 (O25:H4), associated with the CTX-M-15 extended-spectrum beta-lactamase, has emerged internationally as a multidrug-resistant pathogen but has receivedExpand
The Epidemic of Extended-Spectrum-β-Lactamase-Producing Escherichia coli ST131 Is Driven by a Single Highly Pathogenic Subclone, H30-Rx
P pulsed-field gel electrophoresis and whole-genome sequencing are applied to reconstruct the evolutionary history of the ST131 clone and suggest that the high prevalence of CTX-M-15 production among ST131 isolates is due primarily to the expansion of a single, highly virulent subclone, H30-Rx. Expand
Epidemic Clonal Groups of Escherichia coli as a Cause of Antimicrobial-Resistant Urinary Tract Infections in Canada, 2002 to 2004
Findings indicate that among the E. coli urine isolates studied, resistance to TS and FQs has a prominent clonal component, with the O15:K52:H1 clonal group and especially E. bacteria ST131 being the major contributors. Expand
Abrupt emergence of a single dominant multidrug-resistant strain of Escherichia coli.
Most current fluoroquinolone-resistant E. coli clinical isolates represent a highly clonal subgroup that likely originated from a single rapidly expanded and disseminated ST131 strain, which expanded abruptly after 2000. Expand
Escherichia coli sequence type 131 (ST131) subclone H30 as an emergent multidrug-resistant pathogen among US veterans.
Focused attention to ST131, especially its H30 subclone, could reduce infection-related morbidity, mortality, and costs among veterans and accounts for most antimicrobial-resistant E. coli. Expand
Extended-spectrum β-lactamase-producing Escherichia coli from retail chicken meat and humans: comparison of strains, plasmids, resistance genes, and virulence factors.
Significant genetic similarities among ESBL-EC isolates from chicken meat and humans according to mobile resistance elements, virulence genes, and genomic backbone are found and raises serious food safety questions regarding the abundant presence of ES BL-EC in chicken meat. Expand
Molecular Epidemiology and Phylogenetic Distribution of the Escherichia coli pks Genomic Island
The pks island was significantly associated with bacteremia, multiple ExPEC-associated virulence genes, and group B2, and within group B1, it identified an especially high-virulence subset, which supports investigation of the colibactin system as a potential therapeutic target. Expand
The Clonal Distribution and Diversity of Extraintestinal Escherichia coli Isolates Vary According to Patient Characteristics
The distribution and diversity of STs among extraintestinal E. coli clinical isolates vary by patient age, type of infection, and resistance phenotype, whereas other well-known pathogenic lineages are more common among adolescents and young adults, CA infections, and antimicrobial-susceptible isolates. Expand
Escherichia coli Pyomyositis: an emerging infectious disease among patients with hematologic malignancies.
E. coli pyomyositis has emerged as a serious problem among patients with hematologic malignancy and awareness of this emerging syndrome and the usual causative agent is important to ensure appropriate management when febrile, neutropenic patients withHematologic Malignancy exhibit signs of localized muscle infection. Expand
Four Main Virotypes among Extended-Spectrum-β-Lactamase-Producing Isolates of Escherichia coli O25b:H4-B2-ST131: Bacterial, Epidemiological, and Clinical Characteristics
These findings uniquely define four main virotypes, which are internationally distributed, correspond with pulsed-field gel electrophoresis (PFGE) profiles, and exhibit distinctive clinical-epidemiological associations. Expand