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Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1 receptor-deficient mice.
It is demonstrated that adenosine acting on A1R is required for TGF and modulates renin release. Expand
Stimulation of high-affinity adenosine A2 receptors decreases the affinity of dopamine D2 receptors in rat striatal membranes.
Since high-affinity adenosine A2 receptors (A2a) are localized exclusively in dopamine-rich regions in the central nervous system and mediate inhibition of locomotor activity, we have examined theExpand
Differences in the regional and cellular localization of c-fos messenger RNA induced by amphetamine, cocaine and caffeine in the rat
Each of the different CNS stimulant drugs induces a highly specific pattern of c-fos messenger RNA, which is concluded to be similar to that experienced with amphetamine and cocaine. Expand
Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: A role for intraneuronal amyloid
Emerging evidence indicates that intraneuronal accumulation of Abeta may also contribute to the cascade of neurodegenerative events and strongly suggest that it is an early, pathological biomarker for the onset of AD and associated cognitive and other behavioral deficits at ages when overt neuropathology is not yet observed. Expand
Sleep and its homeostatic regulation in mice lacking the adenosine A1 receptor
It is concluded that constitutional lack of adenosine A1R does not prevent the homeostatic regulation of sleep and that rapid eye movement sleep (REM sleep) nor non‐REM sleep (NREMS) amounts differed significantly between the groups. Expand
Mice lacking the adenosine A1 receptor are anxious and aggressive, but are normal learners with reduced muscle strength and survival rate
Results confirm the involvement of adenosine in motor activity, exploratory behaviour, anxiety and aggressiveness in mice lacking A1Rs and also appear to play a critical role in ageing‐related deterioration. Expand
Evidence for functionally important adenosine A2a receptors in the rat hippocampus
The results suggest that adenosine A2a receptor-mediated neuromodulation is not confined to the basal ganglia, but is more widespread throughout the nervous system. Expand
Long‐term Treatment with some Methylxanthines Decreases the Susceptibility to Bicuculline‐ and Pentylenetetrazol‐induced Seizures in Mice. Relationship to c‐ios Expression and Receptor Binding
Results show that long‐term treatment with caffeine in a dose that is commonly seen in humans decreases the seizures induced by bicuculline, and to a lesser extent, those induced by PTZ. Expand
The adenosine A1 receptor contributes to the stimulatory, but not the inhibitory effect of caffeine on locomotion: a study in mice lacking adenosine A1 and/or A2A receptors
The results suggest that the inhibitory effect of high doses of caffeine is due neither to blockade of the A1R, nor ofThe A2AR, and an effect independent of these adenosine receptors is likely. Expand
Modulation of Hippocampal Glutamatergic Transmission by ATP Is Dependent on Adenosine A1 Receptors
Results show that even supposedly stable adenine nucleotides are rapidly converted to adenosine at sites close to the A1 receptor, and that inhibition of synaptic transmission by purineucleotides is mediated exclusively by A1 receptors. Expand