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LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation
Myoblast transcriptome analyses indicated that selective disruption of the LBR- or lamin-A-dependent heterochromatin tethers have opposite effects on muscle gene expression, either increasing or decreasing, respectively. Expand
Nuclear Architecture of Rod Photoreceptor Cells Adapts to Vision in Mammalian Evolution
It is shown that the nuclear architecture of rod photoreceptor cells differs fundamentally in nocturnal and diurnal mammals and suggests that the conventional architecture prevails in eukaryotic nuclei because it results in more flexible chromosome arrangements, facilitating positional regulation of nuclear functions. Expand
Chromatin domains and the interchromatin compartment form structurally defined and functionally interacting nuclear networks
It is demonstrated that most chromatin exists in the form of higher-order chromatin domains with a compaction level at least 10 times above the level of extended 30 nm chromatin fibers, which demonstrates the existence of the IC as a dynamic, structurally distinct nuclear compartment, which is functionally linked with the chromatin compartment. Expand
Epigenomic differentiation in mouse preimplantation nuclei of biparental, parthenote and cloned embryos
Despite differences in the frequencies and the time-course of nuclear architecture reprogramming events, by the eight-cell stage P and NT embryos achieved the same distinct nuclear organization in the majority of embryos as observed for IVF embryos, which suggests that the epigenome of the three types of embryos partially acts as a constraint of the nuclear organization of theThree nuclear subcompartments analysed. Expand
Heterochromatin drives compartmentalization of inverted and conventional nuclei
Attractions between heterochromatic regions are essential for phase separation of the active and inactive genome in inverted and conventional nuclei, whereas chromatin–lamina interactions are necessary to build the conventional genomic architecture from these segregated phases. Expand
Spatial quantitative analysis of fluorescently labeled nuclear structures: Problems, methods, pitfalls
The vast majority of microscopic data in biology of the cell nucleus is currently collected using fluorescence microscopy, and most of these data are subsequently subjected to quantitative analysis.Expand
Distribution of the Mycobacterium community and polycyclic aromatic hydrocarbons (PAHs) among different size fractions of a long-term PAH-contaminated soil.
PAH-degrading mycobacteria are mainly associated with the PAH-enriched clay fraction of the examined PAH -contaminated soil and hence, it is demonstrated that also in the environmental setting of a PAh-contaminate soil, Mycobacterium might experience advantages connected to substrate source attachment. Expand
Transcription on lampbrush chromosomes of a centromerically localized highly repeated DNA in pigeon (Columba) relates to sequence arrangement
It is proposed that transcription of the noncoding PR1 sequence on lampbrush chromosomes of pigeons relates to its genomic organization and is discussed with regard to the ‘read-through’ hypothesis for transcription on lamp brush loops. Expand
Differentiation and large scale spatial organization of the genome.
New results suggest that the spatial organization of chromatin in embryonic stem cells may be important for maintenance of the pluripotent state, whereas the nuclear architecture of differentiated cells facilitates formation of transcriptionally active zones with shared transcription and splicing machinery. Expand
A new variant of the neodermatan‐type spermiogenesis in a parasitic ‘turbellarian’, Notentera ivanovi (Platyhelminthes) and the origin of the Neodermata
It is argued that a high-ranked taxon should be established within the Neoophora to include Notentera and the closely related Fecampiidae and that all the Platyhelminthes with neodermatan-type spermiogenesis form a monophyletic taxon, the Revertospermata, which includes the sister groups Fecampsiida and Mediofusata. Expand