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Conversion of Acetaminophen to the Bioactive N-Acylphenolamine AM404 via Fatty Acid Amide Hydrolase-dependent Arachidonic Acid Conjugation in the Nervous System*
TLDR
It is shown that acetaminophen, following deacetylation to its primary amine, is conjugated with arachidonic acid in the brain and the spinal cord to form the potent TRPV1 agonist N-arachidonoylphenolamine (AM404), which acts on the endogenous cannabinoid system, which, together with TRV1 and COX, is present in the pain and thermoregulatory pathways. Expand
Urinary Phthalate Metabolites and Biomarkers of Reproductive Function in Young Men
TLDR
The observed weak associations between 1 phthalate biomarker and impairment of a few aspects of reproductive function biomarkers were not consistent with results from a recent U.S. study, but phthalic acid actually was associated with improved function, as measured by several markers. Expand
Endogenous Unsaturated C18 N-Acylethanolamines Are Vanilloid Receptor (TRPV1) Agonists*
TLDR
It is shown that several endogenous non-cannabinoid NAEs, many of which are more abundant than anandamide in rat tissues, activate TRPV1 and thus may play a role as endogenous TRPv1 modulators. Expand
Exposure determinants of phthalates, parabens, bisphenol A and triclosan in Swedish mothers and their children
TLDR
There were fairly good correlations of biomarker levels between the mothers and their children and the levels of high molecular weight phthalates and parabens were associated with consumption of certain foods and use of cosmetics and personal care products. Expand
Lead, mercury, and cadmium in blood and their relation to diet among Swedish adults.
TLDR
Body burdens of the studied metals were generally below health based reference values, but several individuals had blood Pb levels above the reference point for possible nephrotoxic and developmental neurotoxic effects. Expand
Intra-individual variations and time trends 1991-2001 in human serum levels of PCB, DDE and hexachlorobenzene.
TLDR
A continuing decrease in human body burdens of PCBs, DDE and HCB during the 1990s is supported, with the explanatory factors relative change of BMI and fish consumption explained only a minor part of the time-related variations in serum levels. Expand
PVC flooring is related to human uptake of phthalates in infants.
TLDR
The findings indicate that the use of soft PVC as flooring material may increase the human uptake of phthalates in infants, and this new information should be considered when designing indoor environment, especially for children. Expand
Hydroxy-PCBs, PBDEs, and HBCDDs in serum from an elderly population of Swedish fishermen's wives and associations with bone density.
TLDR
No associations were found between bone mineral density or biochemical markers of bone metabolism and the analyzed environmental pollutants, and the association between these pollutants and bone density was investigated. Expand
Phosphatidylethanol in human organs and blood: a study on autopsy material and influences by storage conditions.
TLDR
The rat experiments indicated that the very high PEth concentrations found in the organs of the alcoholics were probably largely formed while the organs were frozen at -20 degrees C, and tissue material from bodies that were exposed to ethanol must be stored properly to obtain reliable results from subsequent analysis for PEth. Expand
Effects of diesel exposure on lung function and inflammation biomarkers from airway and peripheral blood of healthy volunteers in a chamber study
TLDR
Diesel exhaust induced acute adverse effects such as symptoms and signs of irritation, decreased PEF, inflammatory markers in healthy volunteers, and a trend towards increased serum IL-6 concentrations was observed 20 h post-exposure. Expand
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