• Publications
  • Influence
Platelet function analyzer (PFA-100): a tool to quantify congenital or acquired platelet dysfunction.
  • B. Jilma
  • Medicine, Chemistry
  • The Journal of laboratory and clinical medicine
  • 1 September 2001
PRINCIPLE OF THE TEST SYSTEM The instrument aspirates a blood sample under constant vacuum from the sample reservoir through a capillary and a microscopic aperture (147 μm) cut into the membrane. TheExpand
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Validation of rotation thrombelastography in a model of systemic activation of fibrinolysis and coagulation in humans.
BACKGROUND Thrombelastography (TEG) is a whole blood assay to evaluate the viscoelastic properties during blood clot formation and clot lysis. Rotation thrombelastography (e.g. ROTEM) has overcomeExpand
  • 148
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Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura.
BACKGROUND Acquired thrombotic thrombocytopenic purpura (TTP) is caused by aggregation of platelets on ultralarge von Willebrand factor multimers. This microvascular thrombosis causes multiorganExpand
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Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel.
BACKGROUND Clopidogrel is activated by CYP2C19, which also metabolizes proton pump inhibitors (PPI). As proton pump inhibitors are metabolized to varying degrees by CYP2C19, we hypothesized that theExpand
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Von Willebrand Factor in Cardiovascular Disease: Focus on Acute Coronary Syndromes
von Willebrand factor (VWF) plays a pivotal role in platelet adhesion and aggregation at sites of high shear rates (eg, in coronary arteries that have stenotic or ruptured atherosclerotic plaqueExpand
  • 296
  • 6
Thrombin as a multi-functional enzyme. Focus on in vitro and in vivo effects.
Thrombin is the central protease in the coagulation cascade and one of the most extensively studied of all enzymes. In addition to its recognised role in the coagulation cascade and haemostasis,Expand
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Recombinant human activated protein C (rhAPC; drotrecogin alfa [activated]) has minimal effect on markers of coagulation, fibrinolysis, and inflammation in acute human endotoxemia.
Inflammatory and procoagulant host responses are closely related in sepsis. The protein C pathway serves as a regulatory pathway with anti-inflammatory and anticoagulant properties. Recently,Expand
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Induction of microparticle- and cell-associated intravascular tissue factor in human endotoxemia.
The precise role of intravascular tissue factor (TF) remains poorly defined, due to the limited availability of assays capable of measuring circulating TF procoagulant activity (PCA). As a model ofExpand
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Regulation of adhesion molecules during human endotoxemia. No acute effects of aspirin.
Gram-negative septic shock is mediated in part by endotoxin (lipopolysaccharide; LPS), and animal models have shown that blockade of even single adhesion molecules considerably improves survival.Expand
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Morphine delays and attenuates ticagrelor exposure and action in patients with myocardial infarction: the randomized, double-blind, placebo-controlled IMPRESSION trial
Abstract Aims The currently available data indicate a drug–drug interaction between morphine and oral P2Y12 receptor inhibitors, when administered together. The aim of this trial was to assess theExpand
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