• Publications
  • Influence
On the Origin of Leprosy
Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae. This unculturable pathogen has undergone extensiveExpand
Oral treatment for Mycobacterium ulcerans infection: results from a pilot study in Benin.
Mycobacterium ulcerans infection is responsible for severe skin lesions in sub-Saharan Africa. We enrolled 30 Beninese patients with Buruli ulcers in a pilot study to evaluate efficacy of an oralExpand
Antagonism between isoniazid and the combination pyrazinamide-rifampin against tuberculosis infection in mice.
Mice that had been inoculated intravenously with 6.30 log10 Mycobacterium tuberculosis H37Rv 14 days earlier were administered one of three combinations of drugs, i.e., isoniazid (INH)-rifampinExpand
In Vitro and In Vivo Activities of Moxifloxacin and Clinafloxacin against Mycobacterium tuberculosis
ABSTRACT On 10% oleic acid–albumin–dextrose–catalase-enriched 7H11 agar medium, the MIC at which 90% of the isolates are inhibited for 20 strains of Mycobacterium tuberculosis was 0.5 μg ofExpand
In Vitro and In Vivo Activities of Rifampin, Streptomycin, Amikacin, Moxifloxacin, R207910, Linezolid, and PA-824 against Mycobacterium ulcerans
ABSTRACT Seven antimicrobials were tested in vitro against 29 clinical isolates of Mycobacterium ulcerans. R207910 demonstrated the lowest MIC50 and MIC90, followed by moxifloxacin (MXF),Expand
Molecular detection of rifampin and ofloxacin resistance for patients who experience relapse of multibacillary leprosy.
Molecular detection of rifampin resistance (rpoB analysis) in Mycobacterium leprae was determined for 49 patients who experienced relapse of multibacillary leprosy and for 34 untreated patients.Expand
Effectiveness of various antimicrobial agents against Mycobacterium avium complex in the beige mouse model.
The results of five chemotherapeutic experiments in beige mice infected with organisms of the Mycobacterium avium complex are presented. After monotherapy with various antimicrobial agents for 4Expand
In vitro and in vivo activities of levofloxacin against Mycobacterium tuberculosis.
In tests with 18 drug-susceptible strains of Mycobacterium tuberculosis, the MIC at which 50% of the strains are inhibited by levofloxacin (LVFX) was one dilution less than that at which 50% of theExpand
Dihydropteroate synthase mutations in the folP1 gene predict dapsone resistance in relapsed cases of leprosy.
Molecular detection was compared with the mouse footpad inoculation test for detection of dapsone resistance in 38 strains of Mycobacterium leprae. Mutations of the folP1 gene (at codons 53 or 55)Expand
Experimental Chemotherapy of Mycobacterial Diseases
Experimental chemotherapy of tuberculois provides the opportunity to assess, in vivo, the antimicrobial activity of a newly developed drug in comparison with that of existing drugs, its antagonistic,Expand