• Publications
  • Influence
Rapid Cycling of Lipid Raft Markers between the Cell Surface and Golgi Complex
The endocytic itineraries of lipid raft markers, such as glycosyl phosphatidylinositol (GPI)-anchored proteins and glycosphingolipids, are incompletely understood. Here we show that differentExpand
  • 520
  • 38
  • PDF
Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells
Previous studies provide evidence for an endocytic mechanism in mammalian cells that is distinct from both clathrin-coated pits and caveolae, and is not inhibited by overexpression of GTPase-nullExpand
  • 496
  • 36
Dynamics of putative raft-associated proteins at the cell surface
Lipid rafts are conceptualized as membrane microdomains enriched in cholesterol and glycosphingolipid that serve as platforms for protein segregation and signaling. The properties of these domains inExpand
  • 422
  • 28
Homotypic vacuolar fusion mediated by t- and v-SNAREs
Membrane fusion is necessary both in the eukaryotic secretory pathway and for the inheritance of organelles during the cell cycle. In the secretory pathway, heterotypic fusion takes place betweenExpand
  • 445
  • 24
A distinct class of endosome mediates clathrin-independent endocytosis to the Golgi complex
Mammalian cells endocytose a variety of proteins and lipids without utilising clathrin-coated pits. Detailed molecular mechanisms for clathrin-independent endocytosis are unclear. Several markers forExpand
  • 266
  • 22
SDPR induces membrane curvature and functions in the formation of caveolae
Caveolae are plasma membrane invaginations with a characteristic flask-shaped morphology. They function in diverse cellular processes, including endocytosis. The mechanism by which caveolae areExpand
  • 206
  • 20
A Vacuolar v–t-SNARE Complex, the Predominant Form In Vivo and on Isolated Vacuoles, Is Disassembled and Activated for Docking and Fusion
Homotypic vacuole fusion in yeast requires Sec18p (N-ethylmaleimide–sensitive fusion protein [NSF]), Sec17p (soluble NSF attachment protein [α-SNAP]), and typical vesicle (v) and target membrane (t)Expand
  • 241
  • 17
  • PDF
Molecular Composition and Ultrastructure of the Caveolar Coat Complex
The single protein caveolar coat complex comprises only cavins and caveolins, coats the caveolar bulb, and is probably responsible for creating caveolae.
  • 115
  • 14
  • PDF
Coassembly of Flotillins Induces Formation of Membrane Microdomains, Membrane Curvature, and Vesicle Budding
Endocytosis has a crucial role in many cellular processes. The best-characterized mechanism for endocytosis involves clathrin-coated pits [1], but evidence has accumulated for additional endocyticExpand
  • 211
  • 12
Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis
The pacsin (also termed syndapin) protein family is well characterised structurally. They contain F-BAR domains associated with the generation or maintenance of membrane curvature. The cell biologyExpand
  • 105
  • 12