B. J. McMorran
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Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
To identify multiple sclerosis (MS) susceptibility loci, we conducted a genome-wide association study (GWAS) in 1,618 cases and used shared data for 3,413 controls. We performed replication in an… Expand
Analysis of promoters recognized by PvdS, an extracytoplasmic-function sigma factor protein from Pseudomonas aeruginosa.
The alternative sigma factor PvdS is required by Pseudomonas aeruginosa for initiation of transcription from pyoverdine (pvd) promoters. Two divergent PvdS-dependent promoters (pvdE and pvdF) were… Expand
Characterisation of the pvdE gene which is required for pyoverdine synthesis in Pseudomonas aeruginosa.
Pseudomonas aeruginosa (Pa) strain PAO synthesises a siderophore, pyoverdine (Pvd), when grown under conditions of iron starvation. Pvd consists of a dihydroxyquinoline group attached to an… Expand
Identification of a DNA sequence motif required for expression of iron-regulated genes in pseudomonads
Many bacteria respond to a lack of iron in the environment by synthesizing siderophores, which act as iron-scavenging compounds. Fluorescent pseudomonads synthesize strain-specific but chemically… Expand
CTLA-4 and multiple sclerosis: The A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population
- B. Wray, J. Stankovich, Lucy Whittock, Terence Dwyer, B. J. McMorran
- Biology, Medicine
- Journal of Neuroimmunology
- 30 May 2008
Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single… Expand
Involvement of a transformylase enzyme in siderophore synthesis in Pseudomonas aeruginosa.
Fluorescent pseudomonads produce yellow-green siderophores when grown under conditions of iron starvation. Here, the characterization of the pvdF gene, which is required for synthesis of the… Expand
Ankyrin-1 gene exhibits allelic heterogeneity in conferring protection against malaria
Allelic heterogeneity is a common phenomenon where a gene exhibit different phenotype depending on the nature of genetic mutations. In the context of genes affecting malaria susceptibility, it… Expand
Host Porphobilinogen Deaminase Deficiency Confers Malaria Resistance in Plasmodium chabaudi but Not in Plasmodium berghei or Plasmodium falciparum During Intraerythrocytic Growth
- Cilly Bernardette Schnider, Hao Yang, +10 authors B. J. McMorran
- Frontiers in Cellular and Infection Microbiology
- 3 September 2020
An important component in host resistance to malaria infection are inherited mutations that give rise to abnormalities and deficiencies in erythrocyte proteins and enzymes. Understanding how such… Expand
First Encounter: How Pathogens
Pathogenic organisms trigger numerous signaling pathways that ultimately lead to drastic changes in physiological functions. Apart from altering structure and function of the epithelial tight… Expand
SAT-191 WHOLE GENOME ANALYSIS OF ABORIGINAL AUSTRALIANS REVEALS VARIANTS ASSOCIATED WITH KIDNEY DISEASE
WITH KIDNEY DISEASE 1Wendy Hoy, 2Sudhir Jadhao, 2Arvind Jaya Shankar, 4Russell Thomson, 5John Duncan Mathews, 6,8Chirag Patel, 6,7,8Andrew Mallett, 9Brendan McMorran, 9Simon Foote and 2,3Shivashankar… Expand