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Reversibly Injured, Postischemic Canine Myocardium Retains Normal Contractile Reserve
Transient coronary occlusion (15 minutes) does not result in irreversible myocardial injury but is associated with a depression of contractile function sustained for several hours to days (“stunned… Expand
Activation of the homeostatic intracellular repair response during cardiac surgery.
- S. Jahania, D. Sengstock, +4 authors R. Mentzer
- Journal of the American College of Surgeons
- 1 April 2013
BACKGROUND The homeostatic intracellular repair response (HIR2) is an endogenous beneficial pathway that eliminates damaged mitochondria and dysfunctional proteins in response to stress. The… Expand
Functional effects of enhancing or silencing adenosine A2b receptors in cardiac fibroblasts.
- Y. Chen, Sara A Epperson, +4 authors F. Villarreal
- Biology, Medicine
- American journal of physiology. Heart and…
- 1 December 2004
Cardiac fibroblasts (CF) express adenosine (ADO) receptors, and pharmacological evidence suggests the possible involvement of the A2 (A2a and A2b) receptor (A2aR and A2bR) subtypes in inhibiting cell… Expand
Thromboxane A2 and peptidoleukotrienes contribute to the myocardial ischemia and contractile dysfunction in response to intracoronary infusion of complement C5a in pigs.
Intracoronary infusions of activated complement C5a result in myocardial ischemia, contractile dysfunction, and leukocyte accumulation. The hypothesis was tested that the generation of the coronary… Expand
Gradual onset of myocardial ischemia results in reduced myocardial infarction. Association with reduced contractile function and metabolic downregulation.
- B. Ito
- 1 April 1995
BACKGROUND With moderate reductions in coronary blood flow, adjustments in myocardial metabolism can occur with a normalization of the imbalance between the decreased O2 delivery and tissue O2… Expand
Role of cardiac mast cells in complement C5a-induced myocardial ischemia.
Activated complement component C5a causes myocardial ischemia mediated by thromboxane (Tx) A2 and leukotrienes C4/D4. Blood cells are not involved in either the mediator release or the myocardial… Expand
Carotid Baroreceptor Reflex Coronary Vasodilation in the Dog
The hypothesis that neurally mediated coronary vasodilation occurs as part of the carotid baroreceptor reflex was investigated. The left main coronary artery was cannulated and perfused at constant… Expand
Parasympathetic control of transmural coronary blood flow in dogs.
- J. Reid, B. Ito, A. Huang, C. Buffington, E. Feigl
- The American journal of physiology
- 1 August 1985
The transmural distribution of coronary blood flow was studied during vagal stimulation in closed-chest, morphine- and alpha-chloralose-anesthetized dogs. The left main coronary artery was cannulated… Expand
Modulation of cardiac remodeling by adenosine: In vitro and in vivo effects
- Francisco Villarreal, S. Zimmermann, +4 authors B. Ito
- Molecular and Cellular Biochemistry
The increasing incidence of congestive heart failure has stimulated efforts to develop pharmacologic strategies to prevent or reverse the associated process of adverse cardiac remodeling. The… Expand
Intracoronary versus intravenous effects of cocaine on coronary flow and ventricular function.
BACKGROUND Cocaine use has been associated with cardiomyopathy and ischemic coronary syndromes. However, the pathophysiological mechanisms responsible for these syndromes are not clear and have been… Expand