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Late-life depression, mild cognitive impairment, and dementia: possible continuum?
Clinical and epidemiologic research has focused on the identification of risk factors that may be modified in predementia syndromes, at a preclinical and early clinical stage of dementing disorders,Expand
A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease
Brain accumulation of the amyloid-β (Aβ) peptide is believed to be the initial event in the Alzheimer disease (AD) process. Aβ accumulation begins 15–20 years before clinical symptoms occur, mainlyExpand
Are NSAIDs Useful to Treat Alzheimer's Disease or Mild Cognitive Impairment?
Several epidemiological studies suggest that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) may protect subjects carrying one or more ε4 allele of the apolipoprotein E (APOE ε4)Expand
Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in man.
We evaluated the GH-releasing activity of hexarelin, a new synthetic hexapeptide, after i.v. (1 and 2 micrograms/kg), sc (1.5 and 3 micrograms/kg), intranasal (20 micrograms/kg), and oral (po; 20 andExpand
Diet and Alzheimer’s disease risk factors or prevention: the current evidence
Preventing or postponing the onset of Alzheimer’s disease (AD) and delaying or slowing its progression would lead to a consequent improvement of health status and quality of life in older age.Expand
Alcohol consumption in mild cognitive impairment and dementia: harmful or neuroprotective?
Objective: In several longitudinal studies, light‐to‐moderate drinking of alcoholic beverages has been proposed as being protective against the development of age‐related changes in cognitiveExpand
Bone loss in response to long-term glucocorticoid therapy.
A number of studies have shown that an excess of glucocorticoids induces osteoporosis, but the mechanism(s) and the time course of the reduction of bone mass remain uncertain. In order to clarifyExpand
An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects.
Prednisone-induced insulin resistance may depend on either reduced sensitivity (receptor defect) or reduced response to insulin (postreceptor defect). To clarify the mechanism of prednisone-inducedExpand
Colonic mass movements in idiopathic chronic constipation.
As relatively little is known of human colonic motor activity either in health, or in pathological conditions, we investigated mass movements in 14 chronically constipated patients and 18 healthyExpand
Metabolic syndrome and cognitive impairment: current epidemiology and possible underlying mechanisms.
A possible role of vascular and lifestyle-related factors was recently proposed for age-related changes of cognitive function, predementia syndromes, and cognitive decline of degenerativeExpand