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Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant-like activity.
A bioassay-guided isolation of the ethanol extract from the fruits of Piper longum yielded a known piperidine alkaloid, piperine, as a monoamine oxidase (MAO) inhibitor. Piperine showed an inhibitoryExpand
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Artificial biosynthesis of phenylpropanoic acids in a tyrosine overproducing Escherichia coli strain
BackgroundThe phenylpropanoid metabolites are an extremely diverse group of natural products biosynthesized by plants, fungi, and bacteria. Although these compounds are widely used in human healthExpand
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Chemical constituents from Nelumbo nucifera leaves and their anti-obesity effects.
Nelumbo nucifera Gaertn. (Nymphaeaceae), commonly called lotus, is widely distributed throughout Eastern Asia. It has been used for food and medicine for a long time. A phytochemical investigation ofExpand
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Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production.
Two new sesquiterpene esters, 1beta,8beta-diacetoxyl-6alpha,9alpha-difuroyloxydihydro-beta-agarofuran (1) and 1beta-acetoxyl-2beta,6alpha,9alpha-trifuroyloxydihydro-beta-agarofuran (2), together withExpand
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Monoamine oxidase inhibitory components fromCayratia japonica
Seven flavonoids were isolated from the whole plants and fruits ofCayratia japonica through the activity-guided isolation of a methanol extract using a monoamine oxidase (MAO) inhibition assay as aExpand
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Ursolic acid is a PPAR-α agonist that regulates hepatic lipid metabolism.
In this study, we confirmed that ursolic acid, a plant triterpenoid, activates peroxisome proliferator-activated receptor (PPAR)-α in vitro. Surface plasmon resonance and time-resolved fluorescenceExpand
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Inhibitory effects of coumarins from the stem barks of Fraxinus rhynchophylla on adipocyte differentiation in 3T3-L1 cells.
In the course of screening anti-adipogenic activity of natural products employing the preadipocyte cell line, 3T3-L1 as an in vitro assay system, the EtOAc fraction of the stem barks of FraxinusExpand
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Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages.
Two new isoflavanones (1 and 13), along with 25 known compounds (2-12, 14-27), were isolated from the EtOAc-soluble fraction of the heartwood of Dalbergia odorifera by following their potential toExpand
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Kaurane Diterpene, Kamebakaurin, Inhibits NF-κB by Directly Targeting the DNA-binding Activity of p50 and Blocks the Expression of Antiapoptotic NF-κB Target Genes*
Kaurane diterpenes have been identified from numerous medicinal plants, which have been used for treatment of inflammation and cancer, however, their molecular mechanism of action remains unclear. WeExpand
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Monoamine oxidase inhibitory components from the roots ofSophora flavescens
In our search for monoamine oxidase (MAO) inhibitors from natural resources, we found that the methanol extract of the roots ofSophora flavescens showed an inhibitory effect on mouse brain monoamineExpand
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