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Endovascular Trophoblast Invasion: Implications for the Pathogenesis of Intrauterine Growth Retardation and Preeclampsia
Abstract Maternal uteroplacental blood flow increases during pregnancy. Altered uteroplacental blood flow is a core predictor of abnormal pregnancy. Normally, the uteroplacental arteries are invadedExpand
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Development of the placental villous tree and its consequences for fetal growth.
Co-ordinated development of the fetal villous tree of the placenta is necessary for continued fetal growth and well-being. Before fetal viability, blood vessel development within the developingExpand
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Placental Origins of Preeclampsia: Challenging the Current Hypothesis
Preeclampsia is a major contributor to the maternal and neonatal mortality and morbidity.1,2 It is the 2nd largest cause of maternal mortality worldwide and affects 5% to 7% of pregnant womenExpand
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The anatomy of the normal placenta
  • B. Huppertz
  • Biology, Medicine
  • Journal of Clinical Pathology
  • 28 August 2008
The placenta is the fetal organ providing the interchange between mother and fetus. This organ needs to provide its function such as transport and secretion even during its development and thus allExpand
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Apoptosis and its role in the trophoblast.
During early placentation the trophoblast of the human placenta differentiates to the villous and extravillous types of trophoblast. Villous trophoblast provides the epithelial cover of the placentalExpand
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Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta
Abstract Villous trophoblast in the human placenta consists of a population of proliferating stem cells which differentiate and individually fuse into the syncytiotrophoblast. We studied theExpand
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The apoptosis cascade — morphological and immunohistochemical methods for its visualization
 Apoptosis is involved in morphogenesis of embryonic tissues as well as in homeostasis of adult organs and tissues. It is the main process by which organs maintain cell mass and at the same timeExpand
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Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation.
In the third trimester of normal pregnancy, the mother tolerates daily shedding of several grams of dying placental trophoblast into the maternal circulation. The balance between apoptotic andExpand
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Developmental biology of the placenta and the origins of placental insufficiency.
Defects in all the trophoblast-differentiating pathways--endovascular, interstitial and chorionic villous--play a role in the pathogenesis of early-onset intra-uterine growth restriction (IUGR).Expand
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Macrophage-Induced Apoptosis Limits Endovascular Trophoblast Invasion in the Uterine Wall of Preeclamptic Women
Impaired invasion of uteroplacental arteries by extravillous trophoblast cells is a key pathogenic mechanism of preeclampsia. We previously demonstrated that reduced trophoblast invasion intoExpand
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