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Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications
Hemodynamic shear stress, the blood flow-generated frictional force acting on the vascular endothelial cells, is essential for endothelial homeostasis under normal physiological conditions.Expand
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Interaction of serine acetyltransferase with O‐acetylserine sulfhydrylase active site: Evidence from fluorescence spectroscopy
Serine acetyltransferase is a key enzyme in the sulfur assimilation pathway of bacteria and plants, and is known to form a bienzyme complex with O‐acetylserine sulfhydrylase, the last enzyme in theExpand
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Characteristics of Stem Cells Derived from the Degenerated Human Intervertebral Disc Cartilage Endplate
Introduction Mesenchymal stem cells (MSCs) derived from adult tissues are an important candidate for cell-based therapies and regenerative medicine due to their multipotential differentiationExpand
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The cryo-electron microscopy structure of huntingtin
Huntingtin (HTT) is a large (348 kDa) protein that is essential for embryonic development and is involved in diverse cellular activities such as vesicular transport, endocytosis, autophagy and theExpand
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The active site of O-acetylserine sulfhydrylase is the anchor point for bienzyme complex formation with serine acetyltransferase.
The biosynthesis of cysteine in bacteria and plants is carried out by a two-step pathway, catalyzed by serine acetyltransferase (SAT) and O-acetylserine sulfhydrylase (OASS; O-acetylserine [thiol]Expand
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Increasing Mastectomy Rates Among all Age Groups for Early Stage Breast Cancer: A 10‐Year Study of Surgical Choice
Abstract:  First‐line surgical options for early stage breast cancer and ductal carcinoma in situ include breast conserving surgery or mastectomy. We analyzed factors that influence the receipt ofExpand
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Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway
There is an urgent need for new therapeutic strategies for patients with glioblastoma multiforme (GBM). Previous studies have shown that berberine (BBR), a natural plant alkaloid, has potentExpand
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Adoption as a risk factor for attempted suicide during adolescence.
OBJECTIVE Depression, impulsivity, and aggression during adolescence have been associated with both adoption and suicidal behavior. Studies of adopted adults suggest that impulsivity, even more thanExpand
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WT1 and Pax2 Re-Expression Is Required for Epithelial-Mesenchymal Transition in 5/6 Nephrectomized Rats and Cultured Kidney Tubular Epithelial Cells
Mature tubular epithelial cells in the adult kidney can undergo epithelial-mesenchymal transition (EMT), a phenotypic change that is linked to the pathogenesis of renal interstitial fibrosis. EMT mayExpand
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Structure of serine acetyltransferase in complexes with CoA and its cysteine feedback inhibitor.
Serine acetyltransferase (SAT, EC 2.3.1.30) catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of l-serine to form O-acetylserine, as the first step of a two-step biosyntheticExpand
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