• Publications
  • Influence
Neuronal NADPH diaphorase is a nitric oxide synthase.
NADPH diaphorase histochemistry selectively labels a number of discrete populations of neurons throughout the nervous system. This simple and robust technique has been used in a great manyExpand
  • 1,875
  • 73
  • PDF
Dopamine Uptake through the Norepinephrine Transporter in Brain Regions with Low Levels of the Dopamine Transporter: Evidence from Knock-Out Mouse Lines
Selective blockers of the norepinephrine transporter (NET) inhibit dopamine uptake in the prefrontal cortex. This suggests that dopamine in this region is normally cleared by the somewhat promiscuousExpand
  • 575
  • 51
Neuroadaptation: Incubation of cocaine craving after withdrawal
Relapse to cocaine addiction is frequently associated with subjective reports of craving, a poorly understood state that precedes and accompanies cocaine-seeking behaviours. It has been suggestedExpand
  • 731
  • 49
Time-Dependent Increases in Brain-Derived Neurotrophic Factor Protein Levels within the Mesolimbic Dopamine System after Withdrawal from Cocaine: Implications for Incubation of Cocaine Craving
Using a rat model of drug craving, we found that the responsiveness to cocaine cues progressively increases or incubates over the first 60 d of cocaine withdrawal. Here we studied whether alterationsExpand
  • 507
  • 49
  • PDF
Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self‐administration in rats
Cocaine self‐administration is associated with a propensity to relapse in humans and reinstatement of drug seeking in rats after prolonged withdrawal periods. These behaviors are hypothesized to beExpand
  • 244
  • 31
Incubation of cocaine craving after withdrawal: a review of preclinical data
Using a rat model of drug craving and relapse, we recently found that cocaine seeking induced by re-exposure to drug-associated cues progressively increases over the first 2 months after withdrawalExpand
  • 410
  • 24
Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine.
Chronic treatment of rats with cocaine leads to long-term biochemical changes in the nucleus accumbens (NAc), a brain region implicated in mediating the reinforcing effects of cocaine and other drugsExpand
  • 444
  • 22
Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments
Following chronic cocaine treatment, we have found a long-lasting increase in AP-1 binding in the rat nucleus accumbens and striatum, two important targets of the behavioral effects of cocaine. ThisExpand
  • 541
  • 21
Chronic Fos-Related Antigens: Stable Variants of ΔFosB Induced in Brain by Chronic Treatments
Fos family transcription factors are believed to play an important role in the transcriptional responses of the brain to a variety of stimuli. Previous studies have described 35 and 37 kDa Fos-likeExpand
  • 300
  • 20
Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: Implications for striatal neuronal function
The physiological meaning of the coexpression of adenosine A2A receptors and group I metabotropic glutamate receptors in γ- aminobutyric acid (GABA)ergic striatal neurons is intriguing. Here weExpand
  • 326
  • 20
  • PDF