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Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle.
TLDR
The results suggest that chronic AMPK activation may mediate the effects of muscle contraction on some, but not all, biochemical adaptations of muscle to endurance exercise training. Expand
Chronic activation of 5'-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle.
TLDR
Chronic chemical activation of AMPK results in increases in GLUT-4 protein, hexokinase activity, and glycogen, similarly to those induced by endurance training. Expand
Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase.
TLDR
It is concluded that GEF and MEF2 mediate the AMPK-induced increase in transcription of skeletal muscle GLUT4 and increase in binding to theGLUT4 promoter within 2 h after AICAR treatment. Expand
Insulin stimulation of glucose uptake fails to decrease palmitate oxidation in muscle if AMPK is activated.
TLDR
It is concluded that AMPK activation can prevent high rates of glucose uptake and glycolytic flux from inhibiting palmitate oxidation in predominantly fast-twitch muscle under these conditions. Expand
AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise
TLDR
These data are to the authors' knowledge the first to demonstrate in skeletal muscle in vivo that AMPK is necessary for hypoxia‐induced VEGF mRNA stabilization, acute exercise increases V EGF transcription, inhibition of AMPK augments the VEGf mRNA response to acute exercise, and AMPK regulates basal VEGFs expression and capillarization, but is not necessary for exercise‐induced angiogenesis. Expand
AMP kinase is not required for the GLUT4 response to exercise and denervation in skeletal muscle.
TLDR
It is demonstrated that muscle AMPK is not required for the response of GLUT4 mRNA to exercise and denervation, and that AMPK activation might be responsible for the increase in GLut4 mRNA expression in response to exercise. Expand
Regulation of GLUT4 gene expression during exercise.
  • B. Holmes, G. Dohm
  • Chemistry, Medicine
  • Medicine and science in sports and exercise
  • 1 July 2004
TLDR
There is good evidence that both increased AMPK activity and increased CAMK activity cause increased transcription of the GLUT4 gene, but it remains to be demonstrated that exercise is acting through one or both of these mechanisms. Expand
mitochondrial enzymes in skeletal muscle Activation of AMP-activated protein kinase increases
[PDF] [Full Text] [Abstract] , September , 2011; 52 (9): 1702-1711. J. Lipid Res. Ceddia Mandeep P. Gaidhu, Andrea Frontini, Steven Hung, Kathryn Pistor, Saverio Cinti and Rolando B. metabolism andExpand
Delta-like Protein 3 Prevalence in Small Cell Lung Cancer and DLL3 (SP347) Assay Characteristics.
TLDR
The study findings provided the profile of D LL3 staining characteristics that can be used for determining the level of DLL3 expression in small cell lung cancer. Expand
Regulation of muscle GLUT 4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase
Burton F. Holmes, David P. Sparling, Ann Louise Olson , William W. Winder, and G. Lynis Dohm Department of Exercise and Sport Science, Human Performance Laboratory and Department of Physiology, BrodyExpand
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