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Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo
The mechanism by which an elongated polyglutamine sequence causes neurodegeneration in Huntington's disease (HD) is unknown. In this study, we show that the proteolytic cleavage of a GST-huntingtin… Expand
Selenite supplementation in euthyroid subjects with thyroid peroxidase antibodies
Euthyroid thyroid peroxidase (TPO‐Ab)‐positive subjects are at risk for progression to subclinical and overt autoimmune hypothyroidism. Previous studies have shown a decrease in TPO‐Ab and… Expand
Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency.
- L. Rasmussen, L. Schomburg, +6 authors Peter Laurberg
- European journal of endocrinology
- 1 April 2011
OBJECTIVE The objective was to study the associations between serum selenium concentration and thyroid volume, as well as the association between serum selenium concentration and risk for an enlarged… Expand
Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice.
- K. Renko, Margarethe Werner, +7 authors U. Schweizer
- Biology, Medicine
- The Biochemical journal
- 1 February 2008
SePP (selenoprotein P) is central for selenium transport and distribution. Targeted inactivation of the Sepp gene in mice leads to reduced selenium content in plasma, kidney, testis and brain.… Expand
Down‐regulation of the hepatic selenoprotein biosynthesis machinery impairs selenium metabolism during the acute phase response in mice
- K. Renko, P. Hofmann, +5 authors L. Schomburg
- Medicine, Biology
- FASEB journal : official publication of the…
- 1 June 2009
The acute‐phase response (APR) is characterized by an impaired metabolism of the essential trace element selenium (Se). Moreover, low‐Se concentrations correlate to mortality risk in sepsis.… Expand
Serum selenium and selenoprotein P status in adult Danes - 8-year followup.
- L. Rasmussen, B. Hollenbach, +6 authors L. Schomburg
- Journal of trace elements in medicine and biology…
- 1 November 2009
Selenium is an essential micronutrient important to human health. The main objective of this study is to describe serum selenium and selenoprotein P status in two samples of the Danish population. In… Expand
Huntingtin aggregation monitored by dynamic light scattering.
- Y. Georgalis, E. Starikov, +5 authors E. Wanker
- Medicine, Chemistry
- Proceedings of the National Academy of Sciences…
- 26 May 1998
An initial stage of fibrillogenesis in solutions of glutathione S-transferase-huntingtin (GST-HD) fusion proteins has been studied by using dynamic light scattering. Two GST-HD systems with… Expand
Aggregation of truncated GST-HD exon 1 fusion proteins containing normal range and expanded glutamine repeats.
- B. Hollenbach, E. Scherzinger, K. Schweiger, R. Lurz, H. Lehrach, E. Wanker
- Biology, Medicine
- Philosophical transactions of the Royal Society…
- 29 June 1999
We have shown previously by electron microscopy that the purified glutathione S-transferase (GST)-Huntington's disease (HD) exon 1 fusion protein with 51 glutamine residues (GST-HD51) is an oligomer,… Expand
Selenium Status Is Positively Associated with Bone Mineral Density in Healthy Aging European Men
Objective It is still a matter of debate if subtle changes in selenium (Se) status affect thyroid function tests (TFTs) and bone mineral density (BMD). This is particularly relevant for the elderly,… Expand
Reduced Serum Selenoprotein P Concentrations in German Prostate Cancer Patients
- H. Meyer, B. Hollenbach, +6 authors L. Schomburg
- Cancer Epidemiology, Biomarkers & Prevention
- 1 September 2009
Selenium (Se) is essentially needed for the biosynthesis of selenoproteins. Low Se intake causes reduced selenoprotein biosynthesis and constitutes a risk factor for tumorigenesis. Accordingly, some… Expand