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Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo
The mechanism by which an elongated polyglutamine sequence causes neurodegeneration in Huntington's disease (HD) is unknown. In this study, we show that the proteolytic cleavage of a GST-huntingtinExpand
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Selenite supplementation in euthyroid subjects with thyroid peroxidase antibodies
Euthyroid thyroid peroxidase (TPO‐Ab)‐positive subjects are at risk for progression to subclinical and overt autoimmune hypothyroidism. Previous studies have shown a decrease in TPO‐Ab andExpand
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Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency.
OBJECTIVE The objective was to study the associations between serum selenium concentration and thyroid volume, as well as the association between serum selenium concentration and risk for an enlargedExpand
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Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice.
SePP (selenoprotein P) is central for selenium transport and distribution. Targeted inactivation of the Sepp gene in mice leads to reduced selenium content in plasma, kidney, testis and brain.Expand
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Down‐regulation of the hepatic selenoprotein biosynthesis machinery impairs selenium metabolism during the acute phase response in mice
The acute‐phase response (APR) is characterized by an impaired metabolism of the essential trace element selenium (Se). Moreover, low‐Se concentrations correlate to mortality risk in sepsis.Expand
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Serum selenium and selenoprotein P status in adult Danes - 8-year followup.
Selenium is an essential micronutrient important to human health. The main objective of this study is to describe serum selenium and selenoprotein P status in two samples of the Danish population. InExpand
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Huntingtin aggregation monitored by dynamic light scattering.
An initial stage of fibrillogenesis in solutions of glutathione S-transferase-huntingtin (GST-HD) fusion proteins has been studied by using dynamic light scattering. Two GST-HD systems withExpand
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Aggregation of truncated GST-HD exon 1 fusion proteins containing normal range and expanded glutamine repeats.
We have shown previously by electron microscopy that the purified glutathione S-transferase (GST)-Huntington's disease (HD) exon 1 fusion protein with 51 glutamine residues (GST-HD51) is an oligomer,Expand
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Selenium Status Is Positively Associated with Bone Mineral Density in Healthy Aging European Men
Objective It is still a matter of debate if subtle changes in selenium (Se) status affect thyroid function tests (TFTs) and bone mineral density (BMD). This is particularly relevant for the elderly,Expand
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Reduced Serum Selenoprotein P Concentrations in German Prostate Cancer Patients
Selenium (Se) is essentially needed for the biosynthesis of selenoproteins. Low Se intake causes reduced selenoprotein biosynthesis and constitutes a risk factor for tumorigenesis. Accordingly, someExpand
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