• Publications
  • Influence
Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation
IN both vertebrates and invertebrates, long-term memory differs from short-term in requiring protein synthesis during training1,2. Studies of the gill and siphon withdrawal reflex in Aplysia indicateExpand
Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons.
Cyclic adenosine monophosphate (cAMP)-dependent protein kinase, labeled with fluorescein and rhodamine on the catalytic and regulatory subunits, respectively, was injected into Aplysia sensoryExpand
Roles of PKA and PKC in facilitation of evoked and spontaneous transmitter release at depressed and nondepressed synapses in aplysia sensory neurons
The results suggest that whereas activation of PKA is sufficient to trigger the facilitation of nondepressed synapses, activation of both PKA and PKC is required to facilitate depressedsynapses, with the contribution of PKC becoming progressively more important as synaptic transmission becomes more depressed. Expand
Second messengers involved in the two processes of presynaptic facilitation that contribute to sensitization and dishabituation in Aplysia sensory neurons.
It is shown here that release of free cyclic AMP from a photolyzable analogue introduced into sensory neurons can enhance release even at depressed synapses, indicating that cyclic PMP can activate the second as well as the first process, and that both cyclicAMP-dependent kinase and protein kinase C may be involved in facilitation of depressedsynapses. Expand
Additional component in the cellular mechanism of presynaptic facilitation contributes to behavioral dishabituation in Aplysia.
It is reported that an additional set of processes also contributes to facilitation of transmitter release from mechanoreceptor sensory neurons that innervate the siphon skin and synapse with interneurons and motor neurons. Expand
Motor primitives in vertebrates and invertebrates
  • T. Flash, B. Hochner
  • Computer Science, Medicine
  • Current Opinion in Neurobiology
  • 1 December 2005
This work has suggested that motor and movement primitives and modules might exist at the neural, dynamic and kinematic levels with complicated mapping among the elementary building blocks subserving these different levels of representation. Expand
Dynamic model of the octopus arm. I. Biomechanics of the octopus reaching movement.
A dynamic model of the octopus arm is presented to explore possible strategies of movement control in this muscular hydrostat and finds that a simple command producing a wave of muscle activation moving at a constant velocity is sufficient to replicate the natural reaching movements with similar kinematic features. Expand
Continuum robot arms inspired by cephalopods
In this paper, we describe our recent results in the development of a new class of soft, continuous backbone ("continuum") robot manipulators. Our work is strongly motivated by the dexterousExpand
Facilitatory transmitters and cAMP can modulate accommodation as well as transmitter release in Aplysia sensory neurons: Evidence for parallel processing in a single cell.
Findings indicate that the same class of mechanisms can, in principle, have a dual action and provide further evidence for parallel processing in the modulation of transmitter release from a single neuron. Expand
Modulation of a transient K+ current in the pleural sensory neurons of Aplysia by serotonin and cAMP: implications for spike broadening.
  • B. Hochner, E. Kandel
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 December 1992
The results support the idea that in the pleural sensory neurons cAMP mediates a significant part of the spike broadening that accompanies short-term facilitation produced by 5-HT and that cAMP can produce spikebroadening by modulating both IKV and IKS. Expand