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Oxidative Stress and Oxidative Damage in Carcinogenesis
Carcinogenesis is a multistep process involving mutation and the subsequent selective clonal expansion of the mutated cell. Chemical and physical agents including those that induce reative oxygenExpand
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The adaptor molecule Disabled‐2 links the transforming growth factor β receptors to the Smad pathway
Using a genetic complementation approach we have identified disabled‐2 (Dab2), a structural homolog of the Dab1 adaptor molecule, as a critical link between the transforming growth factor β (TGFβ)Expand
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TGF‐β induces fibronectin synthesis through a c‐Jun N‐terminal kinase‐dependent, Smad4‐independent pathway
Transforming growth factor‐β (TGF‐β) exerts its effects on cell proliferation, differentiation and migration in part through its modulation of extracellular matrix components, such as fibronectin andExpand
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Regulation of the Wnt signaling pathway by disabled‐2 (Dab2)
The adaptor molecule Disabled‐2 (Dab2) has been shown to link cell surface receptors to downstream signaling pathways. Using a small‐pool cDNA screening strategy, we identify that the N‐terminalExpand
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Thioltransferase in human red blood cells: kinetics and equilibrium.
Thioltransferase from human red blood cells (HRBC TTase), coupled to GSSG reductase, catalyzed glutathione (GSH)-dependent reduction of prototype substrates hydroxyethyl disulfide (HEDS) and sodiumExpand
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Mode of Action analysis of perfluorooctanoic acid (PFOA) tumorigenicity and Human Relevance.
Perfluorooctanoic acid (PFOA) is an environmentally persistent chemical used in the manufacturing of a wide array of industrial and commercial products. PFOA has been shown to induce tumors of theExpand
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Identification of nuclear beta II protein kinase C as a mitotic lamin kinase.
Multisite phosphorylation of the nuclear lamins is thought to regulate the process of mitotic nuclear envelope breakdown in vivo. Here we investigate the involvement of two proposed human mitoticExpand
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TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression.
Recently, a non-DNA binding protein, class II transactivator (CIITA), has been shown to be required for constitutive and IFN-gamma-inducible class II MHC transcription. The cytokine TGF-beta inhibitsExpand
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Disabled-2 (Dab2) Mediates Transforming Growth Factor β (TGFβ)-stimulated Fibronectin Synthesis through TGFβ-activated Kinase 1 and Activation of the JNK Pathway*
The multifunctional cytokine transforming growth factor β (TGFβ) exerts many of its effects through its regulation of extracellular matrix components, including fibronectin (FN). Although expressionExpand
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Wnt Signaling: Physiology and Pathology
Signaling by the Wnt family of secreted glycoproteins has been demonstrated to be essential both in normal embryonic development and in the pathogenesis of a variety of diseases, including cancer.Expand
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