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Surgery to cure the Zollinger-Ellison syndrome.
Association of obesity with hiatal hernia and esophagitis
Excessive body weight is a significant independent risk factor for hiatal hernia and is significantly associated with esophagitis, largely through an increased incidence of hiatAL hernia. Expand
Vitamin B12 deficiency in hypersecretors during long‐term acid suppression with proton pump inhibitors
This work has shown that B12 deficiency elevates methylmalonic acid and homocysteine, both additional markers of B 12 deficiency, and measuring serum B12 alone may underestimate the prevalence. Expand
Quantitative ultrastructural studies on gastric parietal cells.
The data support the theory that the tubulovesicular membrane is incorporated into the secretory membrane as a result of the stimulation, and the production of acid probably takes place mainly at thesecretory surface. Expand
Clinical outcome using lansoprazole in acid hypersecretors with and without Zollinger-Ellison syndrome: a 13-year prospective study.
With individually optimized medical suppression of acid secretion, 90% of patients had good to excellent long-term outcomes without surgery, with an annualized total relapse rate of <5%. Expand
Pharmacological aspects of acid secretion
The finding that H2-receptor antagonists are able to reduce or abolish acid secretion due to vagal, gastrinergic, and histaminergic stimulation shows that histamine plays a pivotal role in stimulation of the parietal cell. Expand
Long‐term lansoprazole control of gastric acid and pepsin secretion in ZE and non‐ZE hypersecretors: a prospective 10‐year study
The majority of patients with Zollinger–Ellison syndrome require lifelong treatment with proton pump inhibitors.
Study of outcome after targeted intervention for peptic ulcer resistant to acid suppression therapy
With current antiulcer therapies, NSAID use is the main, but not the exclusive, factor leading to intractability and complications in refractory ulcers. Expand
Objective evidence of aspirin use in both ulcer and nonulcer upper and lower gastrointestinal bleeding.
The surprisingly high association of current intake of NSAIDs, especially aspirin, with nonulcer GI bleeding including colonic bleeding, changes the conventional view of the following hierarchy of the risk: NSAID----peptic ulcer----bleeding to: NSAIDs----GI bleeding. Expand
Frog Gastric Mucosal ATPase.∗
The chloride mechanism has been shown to transport several univalent anions in the mucosa and to have some action on sulfate, therefore the anion pump may be regarded as relatively nonspecific and the hydrogen ion pump is apparently specific for H+. Expand