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Myofibroblasts and mechano-regulation of connective tissue remodelling
- J. Tomasek, G. Gabbiani, B. Hinz, C. Chaponnier, Robert A. Brown
- MedicineNature Reviews Molecular Cell Biology
- 1 May 2002
It is clear that the understanding of the myofibroblast — its origins, functions and molecular regulation — will have a profound influence on the future effectiveness not only of tissue engineering but also of regenerative medicine generally.
Formation and function of the myofibroblast during tissue repair.
- B. Hinz
- Medicine, BiologyThe Journal of investigative dermatology
- 1 March 2007
Intervention with myofibroblast stress perception and transmission offers novel strategies to reduce tissue contracture; stress release leads to the instant loss of contraction and promotes apoptosis.
Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
It is suggested that lymph nodes and T zone fibroblastic reticular cells have a key function in naive CD4+ and CD8+ T cell homeostasis by providing a limited reservoir of survival factors.
Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix
- P. Wipff, D. Rifkin, J. Meister, B. Hinz
- Biology, MedicineThe Journal of cell biology
- 17 December 2007
It is established that myofibroblast contraction functions as a mechanism to directly activate TGF-β1 from self-generated stores in the extracellular matrix (ECM), restricting autocrine generation of my ofibroblasts to a stiffened ECM.
The myofibroblast: one function, multiple origins.
- B. Hinz, S. Phan, V. Thannickal, A. Galli, M. Bochaton-Piallat, G. Gabbiani
- Medicine, BiologyThe American journal of pathology
- 1 June 2007
A better knowledge of the molecular mechanisms conducive to the appearance of differentiated myofibroblasts in each pathological situation will be useful for the understanding of fibrosis development in different organs and the planning of strategies aiming at their prevention and therapy.
The myofibroblast: paradigm for a mechanically active cell.
- B. Hinz
- Biology, EngineeringJournal of biomechanics
- 5 January 2010
Alpha-smooth muscle actin expression upregulates fibroblast contractile activity.
- B. Hinz, G. Celetta, J. Tomasek, G. Gabbiani, C. Chaponnier
- Biology, MedicineMolecular biology of the cell
- 1 September 2001
An increased alpha-SMA expression is sufficient to enhance fibroblast contractile activity, with the use of silicone substrates of different stiffness degrees.
Recent developments in myofibroblast biology: paradigms for connective tissue remodeling.
Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation.