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Homolog Structure of the SLAC1 Anion Channel for Closing Stomata in Leaves
Conformational features indicate a mechanism for control of gating by kinase activation, and electrostatic features of the pore coupled with electrophysiological characteristics indicate that selectivity among different anions is largely a function of the energetic cost of ion dehydration.
Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily
The high accuracy of the blind prediction of newly characterized enzymes indicates the potential to predict function to the complete polyprenyl transferase subgroup of the isoprenoid synthase superfamily computationally.
A New GntR Family Transcriptional Regulator in Streptomyces coelicolor Is Required for Morphogenesis and Antibiotic Production and Controls Transcription of an ABC Transporter in Response to Carbon
It is suggested that agl3R is one of a number of homologous proteins in Streptomyces that respond to nutritional and/or environmental signals to control genes that affect morphogenesis and antibiotic production.
Structural genomics for drug design against the pathogen Coxiella burnetii
A compound is identified by in silico screening that inhibits CbDHFR with at least 25‐fold greater potency than hDHFR, and could form the basis of a novel antibacterial agent effective against a broad spectrum of pathogenic bacteria.
A New TetR Family Transcriptional Regulator Required for Morphogenesis in Streptomyces coelicolor
It is speculated that the inappropriate expression of xanthine dehydrogenase affects purine salvaging pathways at the onset of development, creating artificially high concentrations of both GTP and ppGpp and perturbing the pathways these molecules participate in for the initiation of morphogenesis and antibiotic production.
Large-Scale Determination of Sequence, Structure, and Function Relationships in Cytosolic Glutathione Transferases across the Biosphere
Global networks of the cytosolic glutathione S-transferases illuminate sequence-structure-function relationships across more than 13,000 members of this superfamily, including experimental
Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes
HpnD catalyzes formation of presqualene diphosphate from two molecules of FPP; HpnC converts PSPP to hydroxysqualene (HSQ); and HpnE, a member of the amine oxidoreductase family, reduces HSQ to SQ, constitute a new pathway for biosynthesis of SQ in bacteria.
Assignment of pterin deaminase activity to an enzyme of unknown function guided by homology modeling and docking.
Of the over 22 million protein sequences in the nonredundant TrEMBL database, fewer than 1% have experimentally confirmed functions. Structure-based methods have been used to predict enzyme
Substrate Distortion and the Catalytic Reaction Mechanism of 5-Carboxyvanillate Decarboxylase
A chemical reaction mechanism for the decarboxylation of 5-carboxyvanillate by LigW was proposed on the basis of the high resolution X-ray structures determined in the presence of ligands bound in the active site, mutation of active site residues, and the magnitude of the product isotope effect determined in a mixture of H2O and D2O.
Structural and mechanistic characterization of L-histidinol phosphate phosphatase from the polymerase and histidinol phosphatase family of proteins.
L-Histidinol phosphate phosphatase (HPP) catalyzes the hydrolysis of L-histidinol phosphate to L-histidinol and inorganic phosphate, the penultimate step in the biosynthesis of L-histidine. HPP from