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Effect of substrate decomposition on the spectrophotometric assay of dihydrofolate reductase.
Abstract 1. (1) Both dihydrofolate and NADPH were found to decompose at a significant rate at pH values below 7, but decomposition of the latter compound was considerably faster than dihydrofolateExpand
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A randomized trial of cisplatin versus cisplatin plus methotrexate in advanced cancer of the urothelial tract.
One hundred eight patients with recurrent or metastatic transitional cell carcinoma of the urothelial tract were randomized to receive cisplatin (C) 80 mg/m2 on day 1 every 4 weeks, or methotrexateExpand
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Calcification of the Meconium within the Bowel of the Newborn
  • B. Hillcoat
  • Medicine
  • Archives of disease in childhood
  • 1 February 1962
Since Neuhauser (I1944) drew attention to the radiological features of intra-abdominal calcification associated with meconium peritonitis, this condition has been diagnosed with increasing frequency.Expand
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Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion.
Concentrations of 5-fluorouracil (FU) were measured in the plasma of patients receiving i.v. infusions of the drug for 5 days as treatment for adenocarcinoma of the gastrointestinal tract.Expand
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Metallothionein induction in mouse tissues by cis-dichlorodiammineplatinum(II) and its hydrolysis products.
cis-Dichlorodiammineplatinum(II) (cis-DDP) doubled the amount of metallothioneins (MTs) in the livers and kidneys of BALB/c mice when injected i.p. in a single high dose of 30 mumol/kg (9 mg/kg). TwoExpand
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Combined actions of 5-fluorouracil and 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea on human colonic carcinoma cells in vitro.
Two lines of human colonic carcinoma cells have different sensitivities to 5-fluorouracil and 1-(2-chlorethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (methyl-CCNU). The growth of the BE line is 50%Expand
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