Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- D. Klionsky, K. Abdelmohsen, S. Zughaier
- BiologyAutophagy
- 18 April 2012
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
Integration of cellular bioenergetics with mitochondrial quality control and autophagy
- B. Hill, G. Benavides, V. Darley-Usmar
- BiologyBiological chemistry
- 1 December 2012
The integration and interpretation of cellular bioenergetics in the context of mitochondrial quality control and genetics is the theme of this review.
Assessing bioenergetic function in response to oxidative stress by metabolic profiling.
- B. Dranka, G. Benavides, V. Darley-Usmar
- BiologyFree Radical Biology & Medicine
- 1 November 2011
Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species.
- B. Dranka, B. Hill, V. Darley-Usmar
- BiologyFree Radical Biology & Medicine
- 1 April 2010
What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology*
- B. Hill, B. Dranka, S. Bailey, J. Lancaster, V. Darley-Usmar
- Biology, ChemistryJournal of Biological Chemistry
- 21 April 2010
This minireview emphasizes the current understanding of the biochemistry of NO and place it in a biological context and highlights a growing importance of the secondary metabolites of NO-dependent reactions in the post-translational modification of key metabolic and signaling proteins.
Cardioprotection by N-Acetylglucosamine Linkage to Cellular Proteins
- Steven P Jones, N. Zachara, E. Marbán
- BiologyCirculation
- 4 March 2008
O-GlcNAc signaling represents a unique endogenously recruitable mechanism of cardioprotection that may involve direct modification of mitochondrial proteins critical for survival such as voltage-dependent anion channel.
Metabolic Coordination of Physiological and Pathological Cardiac Remodeling
- Andrew A Gibb, B. Hill
- Biology, MedicineCirculation Research
- 29 March 2018
This review integrates knowledge of different forms of cardiac remodeling to develop general models of how relationships between catabolic and anabolic glucose metabolism may fortify cardiac health or promote (mal)adaptive myocardial remodeling.
Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal.
- B. Hill, B. Dranka, Luyun Zou, J. Chatham, V. Darley-Usmar
- BiologyBiochemical Journal
- 15 November 2009
It is found that intact rat neonatal ventricular myocytes exhibit a substantial bioenergetic reserve capacity under basal conditions; however, on exposure to pathologically relevant concentrations of HNE, oxygen consumption was increased until this reserve capacity was depleted, suggesting that oxidized lipids could contribute to myocyte injury by decreasing the bioener energetic reserve capacity.
Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis
- J. Salabei, Andrew A Gibb, B. Hill
- BiologyNature Protocols
- 1 February 2014
A detailed XF protocol for measuring respiration in permeabilized cells using a minimal number of cells compared with other protocols and does not require isolation of mitochondria is outlined.
Protein O-GlcNAcylation: a new signaling paradigm for the cardiovascular system.
- B. Laczy, B. Hill, J. Chatham
- BiologyAmerican Journal of Physiology. Heart and…
- 2009
The parallels between O-GlcNAc signaling and redox signaling, as an alternative paradigm for understanding the role of O- GlcNAcylation in regulating cell function, are explored.
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