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Synthesis, storage, and release of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) by human mast cells: implications for the biological significance of VEGF206.
TLDR
The investigation of the possible expression of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in the human mast cell line HMC-1 and in human skin mast cells shows that both normal and leukemic human mast cells constitutively express bioactive VEGF.
EAACI/GA2LEN/EDF guideline: management of urticaria
TLDR
The recommended first line treatment are nonsedating H1 antihistamines, but dosages increased up to fourfold over the recommended doses may be necessary for different urticaria subtypes and in view of individual variation in the course of the disease and response to treatment.
EAACI/GA2LEN/EDF guideline: definition, classification and diagnosis of urticaria
TLDR
This guideline covers the definition and classification of urticaria, taking into account the recent progress in identifying causes, eliciting factors and pathomechanisms of this disease.
Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures
TLDR
VR1 is widely distributed in the skin, suggesting a major role for this receptor, e.g. in nociception and neurogenic inflammation.
C3a and C5a stimulate chemotaxis of human mast cells.
TLDR
Findings indicate that C3a and C5a serve as chemotaxins for human mast cells, indicating that anaphylatoxin-mediated recruitment of mast cells might play an important role in hypersensitivity and inflammatory processes.
What is the physiological function of mast cells?
TLDR
Under physiological conditions, skin mast cells preferentially localize around nerves, blood vessels and hair follicles, suggesting that these enigmatic, multifacetted protagonists of natural immunity are functionally relevant to many more aspects of tissue physiology than just to the generation of inflammatory and vasodilatory responses to IgE‐dependent environmental antigens.
Mast cells as initiators of immunity and host defense
TLDR
The basic ability of mast cells to initiate innate and acquired immune reactions can no longer be questioned and recent evidence attributes a pivotal role to the cells in natural immunity to bacteria.
Human skin: source of and target organ for angiotensin II
TLDR
The findings suggest that the complete renin–angiotensin system is present in human skin and plays a role in normal cutaneous homeostasis as well as in human cutaneous wound healing.
Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo
TLDR
CD437 is identified as a retinoid that activates and upregulates the transcription factor AP-1, leading eventually to programmed cell death of exposed human melanoma cells in vitro and in vivo.
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