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Age-related clonal hematopoiesis associated with adverse outcomes.
Age-related clonal hematopoiesis is a common condition that is associated with increases in the risk of hematologic cancer and in all-cause mortality, with the latter possibly due to an increased risk of cardiovascular disease.
Genome-wide association study identifies novel breast cancer susceptibility loci
To identify further susceptibility alleles, a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls was conducted, followed by a third stage in which 30 single nucleotide polymorphisms were tested for confirmation.
A multiethnic cohort in Hawaii and Los Angeles: baseline characteristics.
As expected, both within and among ethnic groups, the questionnaire data show substantial variations in dietary intakes and in the distributions of non-dietary risk factors (including smoking, alcohol consumption, obesity, and physical activity).
Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor–positive breast cancer
Two SNPs consistently associated with breast cancer are identified: rs3803662 is near the 5′ end of TNRC9 , a high mobility group chromatin–associated protein whose expression is implicated in breast cancer metastasis to bone.
A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China.
A cohort of 18,244 mostly middle-aged (45-64 years) men residing in four small geographically defined areas of Shanghai was accrued between January 1986 and September 1989 and the extent of aflatoxin exposure in the study population was quantitatively estimated.
Multiple regions within 8q24 independently affect risk for prostate cancer
Seven prostate cancer risk variants are identified, five of them previously undescribed, spanning 430 kb and each independently predicting risk for prostate cancer (P = 7.9 × 10−19 for the strongest association), and common genotypes that span a more than fivefold range of susceptibility to cancer in some populations are defined.
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
A meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, and identified 29,807 SNPs for further genotyping suggests that more than 1,000 additional loci are involved in breast cancer susceptibility.
Calibration of the dietary questionnaire for a multiethnic cohort in Hawaii and Los Angeles.
The performance of the dietary questionnaire used in a multiethnic cohort study in Hawaii and Los Angeles was assessed in a calibration substudy that compared diet reported from the questionnaire…
Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men
- M. Freedman, C. Haiman, D. Reich
- MedicineProceedings of the National Academy of Sciences
- 19 September 2006
Admixture mapping indicates a major, still-unidentified risk gene for prostate cancer at 8q24, motivating intense work to find it and finding that the previously described alleles do not explain more than a fraction of the admixture signal.
Choosing Haplotype-Tagging SNPS Based on Unphased Genotype Data Using a Preliminary Sample of Unrelated Subjects with an Example from the Multiethnic Cohort Study
We describe an approach for picking haplotype-tagging single nucleotide polymorphisms (htSNPs) that is presently being taken in two large nested case-control studies within a multiethnic cohort…