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Genome-wide association study identifies novel breast cancer susceptibility loci
To identify further susceptibility alleles, a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls was conducted, followed by a third stage in which 30 single nucleotide polymorphisms were tested for confirmation. Expand
Age-related clonal hematopoiesis associated with adverse outcomes.
- S. Jaiswal, P. Fontanillas, +31 authors B. Ebert
- The New England journal of medicine
- 24 December 2014
Age-related clonal hematopoiesis is a common condition that is associated with increases in the risk of hematologic cancer and in all-cause mortality, with the latter possibly due to an increased risk of cardiovascular disease. Expand
A multiethnic cohort in Hawaii and Los Angeles: baseline characteristics.
- L. Kolonel, B. Henderson, +7 authors F. S. Nagamine
- American journal of epidemiology
- 15 February 2000
As expected, both within and among ethnic groups, the questionnaire data show substantial variations in dietary intakes and in the distributions of non-dietary risk factors (including smoking, alcohol consumption, obesity, and physical activity). Expand
Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor–positive breast cancer
Two SNPs consistently associated with breast cancer are identified: rs3803662 is near the 5′ end of TNRC9 , a high mobility group chromatin–associated protein whose expression is implicated in breast cancer metastasis to bone. Expand
A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China.
- G. Qian, R. Ross, +5 authors J. Groopman
- Cancer epidemiology, biomarkers & prevention : a…
A cohort of 18,244 mostly middle-aged (45-64 years) men residing in four small geographically defined areas of Shanghai was accrued between January 1986 and September 1989 and the extent of aflatoxin exposure in the study population was quantitatively estimated. Expand
Calibration of the dietary questionnaire for a multiethnic cohort in Hawaii and Los Angeles.
The performance of the dietary questionnaire used in a multiethnic cohort study in Hawaii and Los Angeles was assessed in a calibration substudy that compared diet reported from the questionnaire… Expand
Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men
- M. Freedman, C. Haiman, +14 authors D. Reich
- Proceedings of the National Academy of Sciences
- 19 September 2006
Admixture mapping indicates a major, still-unidentified risk gene for prostate cancer at 8q24, motivating intense work to find it and finding that the previously described alleles do not explain more than a fraction of the admixture signal. Expand
Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in southern Guangxi, China.
A positive and almost perfectly linear relationship was observed in the roles of the hepatitis B virus and aflatoxin B1 in the development of primary hepatocellular carcinoma in a cohort of 7917 men aged 25 to 64 yr old in southern Guangxi, China. Expand
Multiple regions within 8q24 independently affect risk for prostate cancer
Seven prostate cancer risk variants are identified, five of them previously undescribed, spanning 430 kb and each independently predicting risk for prostate cancer (P = 7.9 × 10−19 for the strongest association), and common genotypes that span a more than fivefold range of susceptibility to cancer in some populations are defined. Expand
Common variants on chromosome 5p12 confer susceptibility to estrogen receptor–positive breast cancer
A genome-wide association study of breast cancer predisposition with replication and refinement studies involving 6,145 cases and 33,016 controls identified two SNPs on 5p12 that confer risk, preferentially for ER-positive tumors. Expand